| http://purl.uniprot.org/citations/36736301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36736301 | http://www.w3.org/2000/01/rdf-schema#comment | "Inborn errors of human IFN-γ-dependent macrophagic immunity underlie mycobacterial diseases, whereas inborn errors of IFN-α/β-dependent intrinsic immunity underlie viral diseases. Both types of IFNs induce the transcription factor IRF1. We describe unrelated children with inherited complete IRF1 deficiency and early-onset, multiple, life-threatening diseases caused by weakly virulent mycobacteria and related intramacrophagic pathogens. These children have no history of severe viral disease, despite exposure to many viruses, including SARS-CoV-2, which is life-threatening in individuals with impaired IFN-α/β immunity. In leukocytes or fibroblasts stimulated in vitro, IRF1-dependent responses to IFN-γ are, both quantitatively and qualitatively, much stronger than those to IFN-α/β. Moreover, IRF1-deficient mononuclear phagocytes do not control mycobacteria and related pathogens normally when stimulated with IFN-γ. By contrast, IFN-α/β-dependent intrinsic immunity to nine viruses, including SARS-CoV-2, is almost normal in IRF1-deficient fibroblasts. Human IRF1 is essential for IFN-γ-dependent macrophagic immunity to mycobacteria, but largely redundant for IFN-α/β-dependent antiviral immunity."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2022.12.038"xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Hong S.H."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Levy R."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Lee D."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Lachmann N."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Zhao S."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Yang R."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Rice C.M."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Zhang S.Y."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Kremer L."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Perez L."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Molina H."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Gros P."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Khan T."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Daher W."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Casanova J.L."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Manel N."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Abel L."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Bustamante J."xsd:string |
| http://purl.uniprot.org/citations/36736301 | http://purl.uniprot.org/core/author | "Mancini M."xsd:string |