| http://purl.uniprot.org/citations/36762583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36762583 | http://www.w3.org/2000/01/rdf-schema#comment | "The small GTPase Rab22A is an important regulator of the formation of tubular endosomes, which are one of the types of recycling endosome compartments of the clathrin-independent endocytosis pathway. In order to regulate tubular endosome formation, Rab22A must be activated by a specific guanine-nucleotide-exchange factor (GEF); however, all of the GEFs that have been reported to exhibit Rab22A-GEF activity in vitro also activate Rab5A, an essential regulator of the clathrin-mediated endocytosis pathway, and no Rab22A-specific GEF has ever been identified. Here, we identified Vps9d1, a previously uncharacterized vacuolar protein sorting 9 (VPS9) domain-containing protein, as a novel Rab22A-GEF. The formation of tubular endosome structures was found to be severely impaired in Vps9d1-depleted HeLa cells, but Rab5A localization was unaffected. Expression of a constitutively active Rab22A mutant in Vps9d1-depleted HeLa cells restored tubular endosomes, but expression of a GEF-activity-deficient Vps9d1 mutant did not. Moreover, Vps9d1 depletion altered the distribution of clathrin-independent endocytosed cargos and impaired their recycling. Our findings indicate that Vps9d1 promotes tubular endosome formation by specifically activating Rab22A."xsd:string |
| http://purl.uniprot.org/citations/36762583 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.260522"xsd:string |
| http://purl.uniprot.org/citations/36762583 | http://purl.uniprot.org/core/author | "Fukuda M."xsd:string |
| http://purl.uniprot.org/citations/36762583 | http://purl.uniprot.org/core/author | "Nakashima S."xsd:string |
| http://purl.uniprot.org/citations/36762583 | http://purl.uniprot.org/core/author | "Matsui T."xsd:string |
| http://purl.uniprot.org/citations/36762583 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36762583 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/36762583 | http://purl.uniprot.org/core/pages | "jcs260522"xsd:string |
| http://purl.uniprot.org/citations/36762583 | http://purl.uniprot.org/core/title | "Vps9d1 regulates tubular endosome formation through specific activation of Rab22A."xsd:string |
| http://purl.uniprot.org/citations/36762583 | http://purl.uniprot.org/core/volume | "136"xsd:string |
| http://purl.uniprot.org/citations/36762583 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36762583 |
| http://purl.uniprot.org/citations/36762583 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36762583 |
| http://purl.uniprot.org/uniprot/#_H3BM58-mappedCitation-36762583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36762583 |
| http://purl.uniprot.org/uniprot/#_Q96IY7-mappedCitation-36762583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36762583 |
| http://purl.uniprot.org/uniprot/#_Q9UL26-mappedCitation-36762583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36762583 |
| http://purl.uniprot.org/uniprot/#_Q9Y2B5-mappedCitation-36762583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36762583 |
| http://purl.uniprot.org/uniprot/Q9Y2B5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36762583 |
| http://purl.uniprot.org/uniprot/H3BM58 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36762583 |
| http://purl.uniprot.org/uniprot/Q9UL26 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36762583 |
| http://purl.uniprot.org/uniprot/Q96IY7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36762583 |