| http://purl.uniprot.org/citations/36763517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36763517 | http://www.w3.org/2000/01/rdf-schema#comment | "The recurrence of malignancy after hematopoietic cell transplantation (HCT) is the primary cause of transplantation failure. The NKG2D axis is a powerful pathway for antitumor responses, but its role in the control of malignancy after HCT is not well-defined. We tested the hypothesis that gene variation of the NKG2D receptor and its ligands MICA and MICB affect relapse and survival in 1629 patients who received a haploidentical HCT for the treatment of a malignant blood disorder. Patients and donors were characterized for MICA residue 129, the exon 5 short tandem repeat (STR), and MICB residues 52, 57, 98, and 189. Donors were additionally defined for the presence of NKG2D residue 72. Mortality was higher in patients with MICB-52Asn relative to those with 52Asp (hazard ratio [HR], 1.83; 95% confidence interval [CI], 1.24-2.71; P = .002) and lower in those with MICA-STR mismatch than in those with STR match (HR, 0.66; 95% CI, 0.54-0.79; P = .00002). Relapse was lower with NKG2D-72Thr donors than with 72Ala donors (relapse HR, 0.57; 95% CI, 0.35-0.91; P = .02). The protective effects of patient MICB-52Asp with donor MICA-STR mismatch and NKG2D-72Thr were enhanced when all 3 features were present. The NKG2D ligand/receptor pathway is a transplantation determinant. The immunobiology of relapse is defined by the concerted effects of MICA, MICB, and NKG2D germ line variation. Consideration of NKG2D ligand/receptor pairings may improve survival for future patients."xsd:string |
| http://purl.uniprot.org/citations/36763517 | http://purl.org/dc/terms/identifier | "doi:10.1182/bloodadvances.2022008922"xsd:string |
| http://purl.uniprot.org/citations/36763517 | http://purl.uniprot.org/core/author | "He M."xsd:string |
| http://purl.uniprot.org/citations/36763517 | http://purl.uniprot.org/core/author | "Strong R.K."xsd:string |
| http://purl.uniprot.org/citations/36763517 | http://purl.uniprot.org/core/author | "Stevenson P."xsd:string |
| http://purl.uniprot.org/citations/36763517 | http://purl.uniprot.org/core/author | "Hsu K.C."xsd:string |
| http://purl.uniprot.org/citations/36763517 | http://purl.uniprot.org/core/author | "Petersdorf E.W."xsd:string |
| http://purl.uniprot.org/citations/36763517 | http://purl.uniprot.org/core/author | "Malkki M."xsd:string |
| http://purl.uniprot.org/citations/36763517 | http://purl.uniprot.org/core/author | "Gooley T."xsd:string |
| http://purl.uniprot.org/citations/36763517 | http://purl.uniprot.org/core/author | "Spellman S.R."xsd:string |
| http://purl.uniprot.org/citations/36763517 | http://purl.uniprot.org/core/author | "McKallor C."xsd:string |
| http://purl.uniprot.org/citations/36763517 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36763517 | http://purl.uniprot.org/core/name | "Blood Adv"xsd:string |
| http://purl.uniprot.org/citations/36763517 | http://purl.uniprot.org/core/pages | "2888-2896"xsd:string |
| http://purl.uniprot.org/citations/36763517 | http://purl.uniprot.org/core/title | "Role of NKG2D ligands and receptor in haploidentical related donor hematopoietic cell transplantation."xsd:string |
| http://purl.uniprot.org/citations/36763517 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/36763517 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36763517 |
| http://purl.uniprot.org/citations/36763517 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36763517 |
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| http://purl.uniprot.org/uniprot/#_Q1HEA1-mappedCitation-36763517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36763517 |
| http://purl.uniprot.org/uniprot/Q1HEA1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36763517 |
| http://purl.uniprot.org/uniprot/P26718 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36763517 |