| http://purl.uniprot.org/citations/36766705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36766705 | http://www.w3.org/2000/01/rdf-schema#comment | "The human protease Taspase1 plays a pivotal role in developmental processes and cancerous diseases by processing critical regulators, such as the leukemia proto-oncoprotein MLL. Despite almost two decades of intense research, Taspase1's biology is, however, still poorly understood, and so far its cellular function was not assigned to a superordinate biological pathway or a specific signaling cascade. Our data, gained by methods such as co-immunoprecipitation, LC-MS/MS and Topoisomerase II DNA cleavage assays, now functionally link Taspase1 and hormone-induced, Topoisomerase IIβ-mediated transient DNA double-strand breaks, leading to active transcription. The specific interaction with Topoisomerase IIα enhances the formation of DNA double-strand breaks that are a key prerequisite for stimulus-driven gene transcription. Moreover, Taspase1 alters the H3K4 epigenetic signature upon estrogen-stimulation by cleaving the chromatin-modifying enzyme MLL. As estrogen-driven transcription and MLL-derived epigenetic labelling are reduced upon Taspase1 siRNA-mediated knockdown, we finally characterize Taspase1 as a multifunctional co-activator of estrogen-stimulated transcription."xsd:string |
| http://purl.uniprot.org/citations/36766705 | http://purl.org/dc/terms/identifier | "doi:10.3390/cells12030363"xsd:string |
| http://purl.uniprot.org/citations/36766705 | http://purl.uniprot.org/core/author | "Kaschani F."xsd:string |
| http://purl.uniprot.org/citations/36766705 | http://purl.uniprot.org/core/author | "Hensel A."xsd:string |
| http://purl.uniprot.org/citations/36766705 | http://purl.uniprot.org/core/author | "Knauer S.K."xsd:string |
| http://purl.uniprot.org/citations/36766705 | http://purl.uniprot.org/core/author | "Stauber R.H."xsd:string |
| http://purl.uniprot.org/citations/36766705 | http://purl.uniprot.org/core/author | "Stahl P."xsd:string |
| http://purl.uniprot.org/citations/36766705 | http://purl.uniprot.org/core/author | "Oelschlager L."xsd:string |
| http://purl.uniprot.org/citations/36766705 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36766705 | http://purl.uniprot.org/core/name | "Cells"xsd:string |
| http://purl.uniprot.org/citations/36766705 | http://purl.uniprot.org/core/pages | "363"xsd:string |
| http://purl.uniprot.org/citations/36766705 | http://purl.uniprot.org/core/title | "Taspase1 Facilitates Topoisomerase IIbeta-Mediated DNA Double-Strand Breaks Driving Estrogen-Induced Transcription."xsd:string |
| http://purl.uniprot.org/citations/36766705 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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