| http://purl.uniprot.org/citations/36792666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36792666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36792666 | http://www.w3.org/2000/01/rdf-schema#comment | "Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (SVEP1) is an extracellular matrix protein that causally promotes vascular disease and associates with platelet reactivity in humans. Here, using a human genomic and proteomic approach, we identify a high affinity, disease-relevant, and potentially targetable interaction between SVEP1 and the orphan receptor Platelet and Endothelial Aggregation Receptor 1 (PEAR1). This interaction promotes PEAR1 phosphorylation and disease associated AKT/mTOR signaling in vascular cells and platelets. Mice lacking SVEP1 have reduced platelet activation, and exogenous SVEP1 induces PEAR1-dependent activation of platelets. SVEP1 and PEAR1 causally and concordantly relate to platelet phenotypes and cardiovascular disease in humans, as determined by Mendelian Randomization. Targeting this receptor-ligand interaction may be a viable therapeutic strategy to treat or prevent cardiovascular and thrombotic disease."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-36486-0"xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-36486-0"xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Lee P.C."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Lee P.C."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Patel V."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Patel V."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Mecham R.P."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Mecham R.P."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Alisio A."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Alisio A."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Amrute J.M."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Amrute J.M."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Ashworth K.J."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Ashworth K.J."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Burks K.H."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Burks K.H."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Di Paola J."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Di Paola J."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Elenbaas J.S."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Elenbaas J.S."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Halabi C.M."xsd:string |
| http://purl.uniprot.org/citations/36792666 | http://purl.uniprot.org/core/author | "Halabi C.M."xsd:string |