| http://purl.uniprot.org/citations/36804949 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36804949 | http://www.w3.org/2000/01/rdf-schema#comment | "Normal sperm flagellar shape and movement are essential for fertilization. The integral protein outer dense fiber 4 (ODF4) localizes to ODFs, but its function remains unclear. Adenylate kinase (AK) is a phosphotransferase that catalyzes the interconversion and controls the concentration equilibrium of adenine nucleotides. AK shuttles ATP to energy-consuming sites. Here, we report on the relationship of flagellar shape and movement with ODF4, AK1 and AK2 by using Odf4-deletion (Odf4-/-) mice. Soluble ODF4 is coimmunoprecipitated with AK1 and AK2 in Odf4+/+ spermatozoa. ODF4, AK1 and AK2 localize to whole flagella (plasmalemma, mitochondria, ODFs, and residual cytoplasmic droplets (CDs)), principal pieces, and midpieces, respectively. Odf4-/- sperm flagella lose ODF4 and reduce AK1 and AK2 but produce ATP. The flagellum is bent (hairpin flagellum) with a large CD in the midpiece. There is no motility in the midpiece, but the principal piece is motile. Odf4-/- spermatozoa progress backward and fail to ascend in the uterus. Thus, Odf4-/- males are infertile owing to abnormal flagellar shape and movement caused mainly by the loss of ODF4 with AK1 and AK2. This study is supported by the rescue experiment; the abnormalities and male infertility caused by Odf4 deletion were reversed by Odf4 restoration."xsd:string |
| http://purl.uniprot.org/citations/36804949 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-023-28177-z"xsd:string |
| http://purl.uniprot.org/citations/36804949 | http://purl.uniprot.org/core/author | "Ito C."xsd:string |
| http://purl.uniprot.org/citations/36804949 | http://purl.uniprot.org/core/author | "Makino T."xsd:string |
| http://purl.uniprot.org/citations/36804949 | http://purl.uniprot.org/core/author | "Kikkawa M."xsd:string |
| http://purl.uniprot.org/citations/36804949 | http://purl.uniprot.org/core/author | "Toshimori K."xsd:string |
| http://purl.uniprot.org/citations/36804949 | http://purl.uniprot.org/core/author | "Mutoh T."xsd:string |
| http://purl.uniprot.org/citations/36804949 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36804949 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/36804949 | http://purl.uniprot.org/core/pages | "2969"xsd:string |
| http://purl.uniprot.org/citations/36804949 | http://purl.uniprot.org/core/title | "The association of ODF4 with AK1 and AK2 in mice is essential for fertility through its contribution to flagellar shape."xsd:string |
| http://purl.uniprot.org/citations/36804949 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/36804949 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36804949 |
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| http://purl.uniprot.org/uniprot/#_Q8VI88-mappedCitation-36804949 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36804949 |
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| http://purl.uniprot.org/uniprot/#_Q9R0Y5-mappedCitation-36804949 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36804949 |
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| http://purl.uniprot.org/uniprot/Q9WTP6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36804949 |