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| http://purl.uniprot.org/citations/36822364 | http://www.w3.org/2000/01/rdf-schema#comment | "Cystatin C has been linked to inflammation in other diseases, such as epilepsy and Alzheimer's disease. These studies were designed to investigate whether Cystatin C regulates retinal inflammation and permeability. To address this question, we used Cystatin C knockout mice in a retinal ischemia/reperfusion model to determine whether Cystatin C regulated retinal damage, as well as inflammatory mediators and retinal permeability. To support the mouse work, we also used primary retinal endothelial cells cultured in normal and high glucose. Ischemia/reperfusion in Cystatin C knockout mice caused increased formation of degenerate capillaries. Loss of Cystatin C increased fluorescein leakage in the retina, which was accompanied by reduced levels of zonula occludin 1 (ZO-1) and occludin proteins. When REC were grown in high glucose, recombinant Cystatin C decreased retinal permeability, while Cystatin C siRNA increased dextran flux compared to high glucose alone. Recombinant Cystatin C decreased levels of interleukin-1-beta (IL-1β) and high mobility group box 1 (HMGB1) levels. In conclusion, loss of Cystatin C increased vascular damage in response to ischemia/reperfusion. Cystatin C regulated permeability and inflammatory mediators in the retina in response to stressors. Cystatin C offers a new target for retinal disease therapeutic development."xsd:string |
| http://purl.uniprot.org/citations/36822364 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mvr.2023.104510"xsd:string |
| http://purl.uniprot.org/citations/36822364 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/36822364 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/36822364 | http://purl.uniprot.org/core/author | "Steinle J.J."xsd:string |
| http://purl.uniprot.org/citations/36822364 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36822364 | http://purl.uniprot.org/core/name | "Microvasc Res"xsd:string |
| http://purl.uniprot.org/citations/36822364 | http://purl.uniprot.org/core/pages | "104510"xsd:string |
| http://purl.uniprot.org/citations/36822364 | http://purl.uniprot.org/core/title | "Loss of cystatin C regulates permeability and inflammatory pathways in retina."xsd:string |
| http://purl.uniprot.org/citations/36822364 | http://purl.uniprot.org/core/volume | "148"xsd:string |
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