| http://purl.uniprot.org/citations/36822457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36822457 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspase-1 (CASP1)-mediated classical pyroptosis plays a key role in cancer development and management, however, the role of CASP1 and its regulation has not yet been documented for acute promyelocytic leukemia (APL). Here, we found that CASP1/GSDMD had lower expression in patients with APL and most other subtypes of primary de novo acute myeloid leukemia (AML) and was increased in all-trans-retinoic acid (ATRA)-treated APL cells. We showed that ATRA increases and activates CASP1 to trigger the pyroptosis and differentiation of APL cells. Mechanistically, ATRA could induce CASP1 expression via the IFNγ/STAT1 pathway in APL cells. In conclusion, ATRA-induced activation of CASP1 may serve as a suppressor in APL progression, as it triggers pyroptotic cell death and differentiation."xsd:string |
| http://purl.uniprot.org/citations/36822457 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ejphar.2023.175614"xsd:string |
| http://purl.uniprot.org/citations/36822457 | http://purl.uniprot.org/core/author | "Jin S."xsd:string |
| http://purl.uniprot.org/citations/36822457 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/36822457 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/36822457 | http://purl.uniprot.org/core/author | "Tan J."xsd:string |
| http://purl.uniprot.org/citations/36822457 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/36822457 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/36822457 | http://purl.uniprot.org/core/author | "Zeng X."xsd:string |
| http://purl.uniprot.org/citations/36822457 | http://purl.uniprot.org/core/author | "Zeng C."xsd:string |
| http://purl.uniprot.org/citations/36822457 | http://purl.uniprot.org/core/author | "Zhong M."xsd:string |
| http://purl.uniprot.org/citations/36822457 | http://purl.uniprot.org/core/author | "Liu X.'"xsd:string |
| http://purl.uniprot.org/citations/36822457 | http://purl.uniprot.org/core/author | "Nie D."xsd:string |
| http://purl.uniprot.org/citations/36822457 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36822457 | http://purl.uniprot.org/core/name | "Eur J Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/36822457 | http://purl.uniprot.org/core/pages | "175614"xsd:string |
| http://purl.uniprot.org/citations/36822457 | http://purl.uniprot.org/core/title | "Overexpression of CASP1 triggers acute promyelocytic leukemia cell pyroptosis and differentiation."xsd:string |
| http://purl.uniprot.org/citations/36822457 | http://purl.uniprot.org/core/volume | "945"xsd:string |
| http://purl.uniprot.org/citations/36822457 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36822457 |
| http://purl.uniprot.org/citations/36822457 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36822457 |
| http://purl.uniprot.org/uniprot/#_A8K249-mappedCitation-36822457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36822457 |
| http://purl.uniprot.org/uniprot/#_A8K257-mappedCitation-36822457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36822457 |
| http://purl.uniprot.org/uniprot/#_A0A7L9VV54-mappedCitation-36822457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36822457 |
| http://purl.uniprot.org/uniprot/#_A0A8Q3SIY2-mappedCitation-36822457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36822457 |