| http://purl.uniprot.org/citations/36827984 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36827984 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronal activity causes use-dependent decline in protein function. However, it is unclear how this is coupled to local quality control mechanisms. We show in Drosophila that the endocytic protein Endophilin-A (EndoA) connects activity-induced calcium influx to synaptic autophagy and neuronal survival in a Parkinson disease-relevant fashion. Mutations in the disordered loop, including a Parkinson disease-risk mutation, render EndoA insensitive to neuronal stimulation and affect protein dynamics: when EndoA is more flexible, its mobility in membrane nanodomains increases, making it available for autophagosome formation. Conversely, when EndoA is more rigid, its mobility reduces, blocking stimulation-induced autophagy. Balanced stimulation-induced autophagy is required for dopagminergic neuron survival, and a variant in the human ENDOA1 disordered loop conferring risk to Parkinson disease also blocks nanodomain protein mobility and autophagy both in vivo and in human-induced dopaminergic neurons. Thus, we reveal a mechanism that neurons use to connect neuronal activity to local autophagy and that is critical for neuronal survival."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2023.02.001"xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Economou A."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Versees W."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Verstreken P."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Meunier F.A."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Martin E."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Gounko N.V."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Rousseau F."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Sibarita J.B."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Schymkowitz J."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Karamanou S."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Swerts J."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Kuenen S."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Schoovaerts N."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Calatayud C."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Soukup S.F."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Gallego S.F."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Bademosi A.T."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Vints K."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Louros N."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/author | "Decet M."xsd:string |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36827984 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |