| http://purl.uniprot.org/citations/36835034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36835034 | http://www.w3.org/2000/01/rdf-schema#comment | "The increase of vascular arginase activity during aging causes endothelial dysfunction. This enzyme competes with the endothelial nitric oxide synthase (eNOS) for L-arginine substrate. Our hypothesis is that glucose 6-P dehydrogenase (G6PD) overexpression could improve the endothelial function modulating the arginase pathway in aorta from mice. For this study, three groups of male mice were used: young wild type (WT) (6-9 months), old WT (21-22 months) and old G6PD-Tg (21-22 months) mice. Vascular reactivity results showed a reduced acetylcholine-dependent relaxation in the old WT but not old G6PD-Tg group. Endothelial dysfunction was reverted by nor-NOHA, an arginase inhibitor. Mice overexpressing G6PD underexpressed arginase II and also displayed a lower activity of this enzyme. Moreover, histological analyses demonstrated that age causes a thickness of aortic walls, but this did not occur in G6PD-Tg mice. We conclude that the overexpressing G6PD mouse is a model to improve vascular health via the arginase pathway."xsd:string |
| http://purl.uniprot.org/citations/36835034 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms24043622"xsd:string |
| http://purl.uniprot.org/citations/36835034 | http://purl.uniprot.org/core/author | "Valls A."xsd:string |
| http://purl.uniprot.org/citations/36835034 | http://purl.uniprot.org/core/author | "Serna E."xsd:string |
| http://purl.uniprot.org/citations/36835034 | http://purl.uniprot.org/core/author | "Vina J."xsd:string |
| http://purl.uniprot.org/citations/36835034 | http://purl.uniprot.org/core/author | "De la Rosa A."xsd:string |
| http://purl.uniprot.org/citations/36835034 | http://purl.uniprot.org/core/author | "San-Miguel T."xsd:string |
| http://purl.uniprot.org/citations/36835034 | http://purl.uniprot.org/core/author | "Mauricio M.D."xsd:string |
| http://purl.uniprot.org/citations/36835034 | http://purl.uniprot.org/core/author | "Arc-Chagnaud C."xsd:string |
| http://purl.uniprot.org/citations/36835034 | http://purl.uniprot.org/core/author | "Guerra-Ojeda S."xsd:string |
| http://purl.uniprot.org/citations/36835034 | http://purl.uniprot.org/core/author | "Verdu D."xsd:string |
| http://purl.uniprot.org/citations/36835034 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36835034 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/36835034 | http://purl.uniprot.org/core/pages | "3622"xsd:string |
| http://purl.uniprot.org/citations/36835034 | http://purl.uniprot.org/core/title | "Glucose 6-P Dehydrogenase Overexpression Improves Aging-Induced Endothelial Dysfunction in Aorta from Mice: Role of Arginase II."xsd:string |
| http://purl.uniprot.org/citations/36835034 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/36835034 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36835034 |
| http://purl.uniprot.org/citations/36835034 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36835034 |
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| http://purl.uniprot.org/uniprot/#_Q790Y8-mappedCitation-36835034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36835034 |
| http://purl.uniprot.org/uniprot/#_O08691-mappedCitation-36835034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36835034 |
| http://purl.uniprot.org/uniprot/#_Q00612-mappedCitation-36835034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36835034 |
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| http://purl.uniprot.org/uniprot/#_Q8R1Q7-mappedCitation-36835034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36835034 |