| http://purl.uniprot.org/citations/36852510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36852510 | http://www.w3.org/2000/01/rdf-schema#comment | "Mucinous ovarian carcinoma (MOC) is a rare histotype of primary ovarian carcinoma. Frequent pathogenic molecular alterations include mutations in KRAS , TP53 , and overexpression of human epidermal growth factor receptor 2, but without having prognostic relevance. As L1-CAM (cell adhesion molecule) has previously shown prognostic relevance in other epithelial tumors of the female genital tract, we analyzed whether L1-CAM expression affected MOC prognosis. In addition, we investigated L1-CAM expression in mucinous borderline tumors (MBOTs) with and without adjacent MOC to identify its potential role in the pathogenesis of MOC. We examined a well-characterized collective of 39 MOCs by immunohistochemistry and compared their expression with clinicopathologic data. L1-CAM positivity was defined as any (even single-cell) positivity. Furthermore, we compared the L1-CAM expression in 20 MBOT regions adjacent to a MOC with that of 15 pure MBOTs. L1-CAM expression in MOC was significantly associated with recurrence, independent of tumor stage. Overall, 7/20 positive cases recurred versus 0/19 L1-CAM-negative cases ( P =0.032), showing a significant difference in time to progression. Furthermore, the presence of at least 1 defined molecular alteration (L1-CAM, aberrant p53, or human epidermal growth factor receptor 2) was found more frequently in the MBOT regions adjacent to a MOC (14/20) than in pure MBOTs (3/15) ( P =0.024). Expression of the tumor marker L1-CAM is frequent (51%) in MOC and is associated with tumor recurrence. The lack of L1-CAM may serve to characterize cases with a low risk of recurrence. Furthermore, the presence of specific molecular alterations in MBOTs is associated with adjacent carcinomas and may define potential pathways in tumor progression."xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://purl.org/dc/terms/identifier | "doi:10.1097/pas.0000000000002027"xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://purl.uniprot.org/core/author | "Sulyok M."xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://purl.uniprot.org/core/author | "Fend F."xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://purl.uniprot.org/core/author | "Mayr D."xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://purl.uniprot.org/core/author | "Grube M."xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://purl.uniprot.org/core/author | "Brucker S."xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://purl.uniprot.org/core/author | "Pasternak I."xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://purl.uniprot.org/core/author | "Staebler A."xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://purl.uniprot.org/core/author | "Kommoss S."xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://purl.uniprot.org/core/author | "Fischer A.K."xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://purl.uniprot.org/core/author | "Greif K."xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://purl.uniprot.org/core/author | "Schmoeckel E."xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://purl.uniprot.org/core/author | "Beschorner C."xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://purl.uniprot.org/core/author | "Wiedenhoefer R."xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36852510 | http://purl.uniprot.org/core/name | "Am J Surg Pathol"xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://purl.uniprot.org/core/pages | "558-567"xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://purl.uniprot.org/core/title | "L1-CAM in Mucinous Ovarian Carcinomas and Borderline Tumors: Impact on Tumor Recurrence and Potential Role in Tumor Progression."xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/36852510 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36852510 |
| http://purl.uniprot.org/citations/36852510 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36852510 |
| http://purl.uniprot.org/uniprot/#_A8K139-mappedCitation-36852510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36852510 |
| http://purl.uniprot.org/uniprot/#_P32004-mappedCitation-36852510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36852510 |