| http://purl.uniprot.org/citations/36857451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36857451 | http://www.w3.org/2000/01/rdf-schema#comment | "Synaptic zinc ion (Zn2+) has emerged as a key neuromodulator in the brain. However, the lack of research tools for directly tracking synaptic Zn2+ in the brain of awake animals hinders our rigorous understanding of the physiological and pathological roles of synaptic Zn2+. In this study, we developed a genetically encoded far-red fluorescent indicator for monitoring synaptic Zn2+ dynamics in the nervous system. Our engineered far-red fluorescent indicator for synaptic Zn2+ (FRISZ) displayed a substantial Zn2+-specific turn-on response and low-micromolar affinity. We genetically anchored FRISZ to the mammalian extracellular membrane via a transmembrane (TM) ⍺ helix and characterized the resultant FRISZ-TM construct at the mammalian cell surface. We used FRISZ-TM to image synaptic Zn2+ in the auditory cortex in acute brain slices and awake mice in response to electric and sound stimuli, respectively. Thus, this study establishes a technology for studying the roles of synaptic Zn2+ in the nervous system."xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.add2058"xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://purl.uniprot.org/core/author | "Tian X."xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://purl.uniprot.org/core/author | "Zhao S."xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://purl.uniprot.org/core/author | "Wu T."xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://purl.uniprot.org/core/author | "Kumar M."xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://purl.uniprot.org/core/author | "Anderson C.T."xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://purl.uniprot.org/core/author | "McCollum M."xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://purl.uniprot.org/core/author | "Tzounopoulos T."xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://purl.uniprot.org/core/author | "Ai H.W."xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://purl.uniprot.org/core/author | "Drobizhev M."xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://purl.uniprot.org/core/author | "Pokorny A."xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36857451 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://purl.uniprot.org/core/pages | "eadd2058"xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://purl.uniprot.org/core/title | "A genetically encoded far-red fluorescent indicator for imaging synaptically released Zn2."xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/36857451 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36857451 |
| http://purl.uniprot.org/citations/36857451 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36857451 |
| http://purl.uniprot.org/uniprot/#_P97441-mappedCitation-36857451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36857451 |
| http://purl.uniprot.org/uniprot/#_Q3UN07-mappedCitation-36857451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36857451 |