| http://purl.uniprot.org/citations/36859544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36859544 | http://www.w3.org/2000/01/rdf-schema#comment | "The meninges are densely innervated by nociceptive sensory neurons that mediate pain and headache1,2. Bacterial meningitis causes life-threatening infections of the meninges and central nervous system, affecting more than 2.5 million people a year3-5. How pain and neuroimmune interactions impact meningeal antibacterial host defences are unclear. Here we show that Nav1.8+ nociceptors signal to immune cells in the meninges through the neuropeptide calcitonin gene-related peptide (CGRP) during infection. This neuroimmune axis inhibits host defences and exacerbates bacterial meningitis. Nociceptor neuron ablation reduced meningeal and brain invasion by two bacterial pathogens: Streptococcus pneumoniae and Streptococcus agalactiae. S. pneumoniae activated nociceptors through its pore-forming toxin pneumolysin to release CGRP from nerve terminals. CGRP acted through receptor activity modifying protein 1 (RAMP1) on meningeal macrophages to polarize their transcriptional responses, suppressing macrophage chemokine expression, neutrophil recruitment and dural antimicrobial defences. Macrophage-specific RAMP1 deficiency or pharmacological blockade of RAMP1 enhanced immune responses and bacterial clearance in the meninges and brain. Therefore, bacteria hijack CGRP-RAMP1 signalling in meningeal macrophages to facilitate brain invasion. Targeting this neuroimmune axis in the meninges can enhance host defences and potentially produce treatments for bacterial meningitis."xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-023-05753-x"xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/author | "Choi S."xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/author | "Wu G."xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/author | "Yang D."xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/author | "Deng L."xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/author | "Levy D."xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/author | "He K."xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/author | "Chiu I.M."xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/author | "Neel D.V."xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/author | "Doran K.S."xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/author | "Walker A.J."xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/author | "Stevens B."xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/author | "Basu H."xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/author | "Erdogan O."xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/author | "Pinho-Ribeiro F.A."xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/author | "Carneiro-Nascimento S."xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/pages | "472-481"xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/title | "Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion."xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://purl.uniprot.org/core/volume | "615"xsd:string |
| http://purl.uniprot.org/citations/36859544 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36859544 |
| http://purl.uniprot.org/citations/36859544 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36859544 |