| http://purl.uniprot.org/citations/36869047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36869047 | http://www.w3.org/2000/01/rdf-schema#comment | "Medulloblastoma, the most common malignant pediatric brain tumor, often harbors MYC amplifications. Compared to high-grade gliomas, MYC-amplified medulloblastomas often show increased photoreceptor activity and arise in the presence of a functional ARF/p53 suppressor pathway. Here, we generate an immunocompetent transgenic mouse model with regulatable MYC that develop clonal tumors that molecularly resemble photoreceptor-positive Group 3 medulloblastoma. Compared to MYCN-expressing brain tumors driven from the same promoter, pronounced ARF silencing is present in our MYC-expressing model and in human medulloblastoma. While partial Arf suppression causes increased malignancy in MYCN-expressing tumors, complete Arf depletion promotes photoreceptor-negative high-grade glioma formation. Computational models and clinical data further identify drugs targeting MYC-driven tumors with a suppressed but functional ARF pathway. We show that the HSP90 inhibitor, Onalespib, significantly targets MYC-driven but not MYCN-driven tumors in an ARF-dependent manner. The treatment increases cell death in synergy with cisplatin and demonstrates potential for targeting MYC-driven medulloblastoma."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-36847-9"xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/author | "Zhao M."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/author | "Thompson D."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/author | "Hill R.M."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/author | "Richardson S."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/author | "Kasper M."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/author | "Rosen G."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/author | "Sundstrom A."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/author | "Hutter S."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/author | "Clifford S.C."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/author | "Swartling F.J."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/author | "Weishaupt H."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/author | "Annusver K."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/author | "Holmberg K.O."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/author | "Borgenvik A."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/author | "Breinschmid L."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/author | "Mainwaring O.J."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/author | "Verbaan A.D."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/pages | "1221"xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/title | "ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors."xsd:string |
| http://purl.uniprot.org/citations/36869047 | http://purl.uniprot.org/core/volume | "14"xsd:string |