| http://purl.uniprot.org/citations/36884349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36884349 | http://www.w3.org/2000/01/rdf-schema#comment | "Naive CD4+ T cells are more resistant to age-related loss than naive CD8+ T cells, suggesting mechanisms that preferentially protect naive CD4+ T cells during aging. Here, we show that TRIB2 is more abundant in naive CD4+ than CD8+ T cells and counteracts quiescence exit by suppressing AKT activation. TRIB2 deficiency increases AKT activity and accelerates proliferation and differentiation in response to interleukin-7 (IL-7) in humans and during lymphopenia in mice. TRIB2 transcription is controlled by the lineage-determining transcription factors ThPOK and RUNX3. Ablation of Zbtb7b (encoding ThPOK) and Cbfb (obligatory RUNT cofactor) attenuates the difference in lymphopenia-induced proliferation between naive CD4+ and CD8+ cells. In older adults, ThPOK and TRIB2 expression wanes in naive CD4+ T cells, causing loss of naivety. These findings assign TRIB2 a key role in regulating T cell homeostasis and provide a model to explain the lesser resilience of CD8+ T cells to undergo changes with age."xsd:string |
| http://purl.uniprot.org/citations/36884349 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2023.112195"xsd:string |
| http://purl.uniprot.org/citations/36884349 | http://purl.uniprot.org/core/author | "Hu B."xsd:string |
| http://purl.uniprot.org/citations/36884349 | http://purl.uniprot.org/core/author | "Jin J."xsd:string |
| http://purl.uniprot.org/citations/36884349 | http://purl.uniprot.org/core/author | "Fang F."xsd:string |
| http://purl.uniprot.org/citations/36884349 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/36884349 | http://purl.uniprot.org/core/author | "Cao W."xsd:string |
| http://purl.uniprot.org/citations/36884349 | http://purl.uniprot.org/core/author | "Goronzy J.J."xsd:string |
| http://purl.uniprot.org/citations/36884349 | http://purl.uniprot.org/core/author | "Weyand C.M."xsd:string |
| http://purl.uniprot.org/citations/36884349 | http://purl.uniprot.org/core/author | "Jadhav R.R."xsd:string |
| http://purl.uniprot.org/citations/36884349 | http://purl.uniprot.org/core/author | "Sturmlechner I."xsd:string |
| http://purl.uniprot.org/citations/36884349 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36884349 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/36884349 | http://purl.uniprot.org/core/pages | "112195"xsd:string |
| http://purl.uniprot.org/citations/36884349 | http://purl.uniprot.org/core/title | "TRIB2 safeguards naive T cell homeostasis during aging."xsd:string |
| http://purl.uniprot.org/citations/36884349 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/36884349 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36884349 |
| http://purl.uniprot.org/citations/36884349 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36884349 |
| http://purl.uniprot.org/uniprot/#_D3YXC8-mappedCitation-36884349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36884349 |
| http://purl.uniprot.org/uniprot/#_Q08024-mappedCitation-36884349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36884349 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VJR1-mappedCitation-36884349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36884349 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VK24-mappedCitation-36884349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36884349 |
| http://purl.uniprot.org/uniprot/#_D3Z2X8-mappedCitation-36884349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36884349 |
| http://purl.uniprot.org/uniprot/#_D3YZR6-mappedCitation-36884349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36884349 |