| http://purl.uniprot.org/citations/36907288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36907288 | http://www.w3.org/2000/01/rdf-schema#comment | "Normothermic machine perfusion (NMP) could provide a curative treatment to reduce biliary injury in donation after cardiac death (DCD) donor livers; however, the underlying mechanisms remain poorly understood. In a rat model, our study compared air-oxygenated NMP to hyperoxygenated NMP and found that air-oxygenated NMP improved DCD functional recovery. Here, we found that the charged multivesicular body protein 2B (CHMP2B) expression was substantially elevated in the intrahepatic biliary duct endothelium of the cold-preserved rat DCD liver after air-oxygenated NMP or in biliary endothelial cells under hypoxia/physoxia. CHMP2B knockout (CHMP2B-/-) rat livers showed increased biliary injury after air-oxygenated NMP, indicated by decreased bile production and bilirubin level, elevated biliary levels of lactate dehydrogenase and gamma-glutamyl transferase. Mechanically, we demonstrated that CHMP2B was transcriptionally regulated by Kruppel-like transcription factor 6 (KLF6) and alleviated biliary injury through decreasing autophagy. Collectively, our results suggested that air-oxygenated NMP regulates CHMP2B expression through the KLF6, which reduces biliary injury by inhibiting autophagy. Targeting the KLF6-CHMP2B autophagy axis may provide a solution to reducing biliary injury in DCD livers undergoing NMP."xsd:string |
| http://purl.uniprot.org/citations/36907288 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbadis.2023.166686"xsd:string |
| http://purl.uniprot.org/citations/36907288 | http://purl.uniprot.org/core/author | "Bai Y."xsd:string |
| http://purl.uniprot.org/citations/36907288 | http://purl.uniprot.org/core/author | "Jin Y."xsd:string |
| http://purl.uniprot.org/citations/36907288 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
| http://purl.uniprot.org/citations/36907288 | http://purl.uniprot.org/core/author | "Shi J.H."xsd:string |
| http://purl.uniprot.org/citations/36907288 | http://purl.uniprot.org/core/author | "Tang H.W."xsd:string |
| http://purl.uniprot.org/citations/36907288 | http://purl.uniprot.org/core/author | "Zhang J.K."xsd:string |
| http://purl.uniprot.org/citations/36907288 | http://purl.uniprot.org/core/author | "Guo W.Z."xsd:string |
| http://purl.uniprot.org/citations/36907288 | http://purl.uniprot.org/core/author | "Yang D.J."xsd:string |
| http://purl.uniprot.org/citations/36907288 | http://purl.uniprot.org/core/author | "Zhang S.J."xsd:string |
| http://purl.uniprot.org/citations/36907288 | http://purl.uniprot.org/core/author | "Yan Z.P."xsd:string |
| http://purl.uniprot.org/citations/36907288 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36907288 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta Mol Basis Dis"xsd:string |
| http://purl.uniprot.org/citations/36907288 | http://purl.uniprot.org/core/pages | "166686"xsd:string |
| http://purl.uniprot.org/citations/36907288 | http://purl.uniprot.org/core/title | "Charged multivesicular body protein 2B ameliorates biliary injury in the liver from donation after cardiac death rats via autophagy with air-oxygenated normothermic machine perfusion."xsd:string |
| http://purl.uniprot.org/citations/36907288 | http://purl.uniprot.org/core/volume | "1869"xsd:string |
| http://purl.uniprot.org/citations/36907288 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36907288 |
| http://purl.uniprot.org/citations/36907288 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36907288 |
| http://purl.uniprot.org/uniprot/#_A6K4X0-mappedCitation-36907288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36907288 |
| http://purl.uniprot.org/uniprot/#_A0A8L2R4Q4-mappedCitation-36907288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36907288 |
| http://purl.uniprot.org/uniprot/#_A6JLM8-mappedCitation-36907288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36907288 |
| http://purl.uniprot.org/uniprot/#_A6JLM9-mappedCitation-36907288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36907288 |
| http://purl.uniprot.org/uniprot/#_G3V880-mappedCitation-36907288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36907288 |