| http://purl.uniprot.org/citations/36915983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36915983 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutation in the Drosophila melanogaster lethal giant larvae (lgl), a tumor suppressor gene with a well-established role in cellular polarity, is known to results in massive cellular proliferation and neoplastic outgrowths. Although the tumorigenic properties of lgl mutant have been previously studied, however, little is known about its consequences on the proteome. In this study, mass spectrometry-based label-free quantitative proteomics was employed to investigate the changes in the head and intestinal tissues proteins of Drosophila melanogaster, due to lgl mutation and following treatment with melatonin. Additionally, to uncover the time-influenced variations in the proteome during tumorigenesis and melatonin treatment, the rhythmic expression of proteins was also investigated at 6-h intervals within 24-h clock. Together, the present study has identified 434 proteins of altered expressions (p < 0.05 and fold change ±1.5) in the tissues of flies in response to lgl mutation as well as posttreatment with melatonin. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of differentially expressed proteins revealed that lgl mutation had significantly affected the biological functions, including metabolism, and protein synthesis and degradation, in flies' tissues. Besides, melatonin had beneficially mitigated the deleterious effects of lgl mutation by reversing the alterations in protein expression closer to baseline levels. Further, changes in protein expression in the tissues due to lgl mutation and melatonin treatment were found rhythmically orchestrated. Together, these findings provide novel insight into the pathways involved in lgl-induced tumorigenesis as well as demonstrated the efficacy of melatonin as a potential anticancer agent. Data are available via ProteomeXchange with identifier PXD033191."xsd:string |
| http://purl.uniprot.org/citations/36915983 | http://purl.org/dc/terms/identifier | "doi:10.1002/arch.22008"xsd:string |
| http://purl.uniprot.org/citations/36915983 | http://purl.uniprot.org/core/author | "Subramanian P."xsd:string |
| http://purl.uniprot.org/citations/36915983 | http://purl.uniprot.org/core/author | "Wong K.C."xsd:string |
| http://purl.uniprot.org/citations/36915983 | http://purl.uniprot.org/core/author | "Ismail M.N."xsd:string |
| http://purl.uniprot.org/citations/36915983 | http://purl.uniprot.org/core/author | "Abdul-Rahman P.S."xsd:string |
| http://purl.uniprot.org/citations/36915983 | http://purl.uniprot.org/core/author | "Jayapalan J.J."xsd:string |
| http://purl.uniprot.org/citations/36915983 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36915983 | http://purl.uniprot.org/core/name | "Arch Insect Biochem Physiol"xsd:string |
| http://purl.uniprot.org/citations/36915983 | http://purl.uniprot.org/core/pages | "e22008"xsd:string |
| http://purl.uniprot.org/citations/36915983 | http://purl.uniprot.org/core/title | "Label-free quantitative mass spectrometry analysis of the circadian proteome of Drosophila melanogaster lethal giant larvae mutants reveals potential therapeutic effects of melatonin."xsd:string |
| http://purl.uniprot.org/citations/36915983 | http://purl.uniprot.org/core/volume | "113"xsd:string |
| http://purl.uniprot.org/citations/36915983 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36915983 |
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