| http://purl.uniprot.org/citations/36916958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36916958 | http://www.w3.org/2000/01/rdf-schema#comment | "Histone modifications play crucial roles in transcriptional activation, and aberrant epigenetic changes are associated with oncogenesis. Lysine (K) acetyltransferases 5 (TIP60, also known as KAT5) is reportedly implicated in cancer development and maintenance, although its function in lung cancer remains controversial. Here we demonstrate that TIP60 knockdown in non-small cell lung cancer cell lines decreased tumor cell growth, migration, and invasion. Furthermore, analysis of a mouse lung cancer model with lung-specific conditional Tip60 knockout revealed suppressed tumor formation relative to controls, but no apparent effects on normal lung homeostasis. RNA-seq and ChIP-seq analyses of inducible TIP60 knockdown H1975 cells relative to controls revealed transglutaminase enzyme (TGM5) as downstream of TIP60. Investigation of a connectivity map database identified several candidate compounds that decrease TIP60 mRNA, one that suppressed tumor growth in cell culture and in vivo. In addition, TH1834, a TIP60 acetyltransferase inhibitor, showed comparable antitumor effects in cell culture and in vivo. Taken together, suppression of TIP60 activity shows tumor-specific efficacy against lung cancer, with no overt effect on normal tissues. Our work suggests that targeting TIP60 could be a promising approach to treating lung cancer."xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.org/dc/terms/identifier | "doi:10.1111/cas.15785"xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/author | "Fujii M."xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/author | "Jiang F."xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/author | "Pan G."xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/author | "Watanabe H."xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/author | "Ando M."xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/author | "Wong K.K."xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/author | "Tenen D.G."xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/author | "Bararia D."xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/author | "Heo E."xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/author | "Costa D.B."xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/author | "Akanuma N."xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/author | "Kobayashi S.S."xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/author | "Shibahara D."xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/author | "Kobayashi I.S."xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/author | "Prin P.N."xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/name | "Cancer Sci"xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/pages | "2400-2413"xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/title | "TIP60 is required for tumorigenesis in non-small cell lung cancer."xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/36916958 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36916958 |
| http://purl.uniprot.org/citations/36916958 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36916958 |