| http://purl.uniprot.org/citations/36918693 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36918693 | http://www.w3.org/2000/01/rdf-schema#comment | "COVID-19 is a systemic disease involving multiple organs. We previously established a platform to derive organoids and cells from human pluripotent stem cells to model SARS-CoV-2 infection and perform drug screens1,2. This provided insight into cellular tropism and the host response, yet the molecular mechanisms regulating SARS-CoV-2 infection remain poorly defined. Here we systematically examined changes in transcript profiles caused by SARS-CoV-2 infection at different multiplicities of infection for lung airway organoids, lung alveolar organoids and cardiomyocytes, and identified several genes that are generally implicated in controlling SARS-CoV-2 infection, including CIART, the circadian-associated repressor of transcription. Lung airway organoids, lung alveolar organoids and cardiomyocytes derived from isogenic CIART-/- human pluripotent stem cells were significantly resistant to SARS-CoV-2 infection, independently of viral entry. Single-cell RNA-sequencing analysis further validated the decreased levels of SARS-CoV-2 infection in ciliated-like cells of lung airway organoids. CUT&RUN, ATAC-seq and RNA-sequencing analyses showed that CIART controls SARS-CoV-2 infection at least in part through the regulation of NR4A1, a gene also identified from the multi-organoid analysis. Finally, transcriptional profiling and pharmacological inhibition led to the discovery that the Retinoid X Receptor pathway regulates SARS-CoV-2 infection downstream of CIART and NR4A1. The multi-organoid platform identified the role of circadian-clock regulation in SARS-CoV-2 infection, which provides potential therapeutic targets for protection against COVID-19 across organ systems."xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41556-023-01095-y"xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/author | "Evans T."xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/author | "Qiu Y."xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/author | "Tang X."xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/author | "Xiang J."xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/author | "Duan X."xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/author | "Xue D."xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/author | "tenOever B.R."xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/author | "Carrau L."xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/author | "Gordillo M."xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/author | "Schwartz R.E."xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/author | "Tan A.Y."xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/author | "Nilsson-Payant B.E."xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/pages | "381-389"xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/title | "A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection."xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/36918693 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36918693 |
| http://purl.uniprot.org/citations/36918693 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36918693 |
| http://purl.uniprot.org/uniprot/#_Q8N365-mappedCitation-36918693 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36918693 |