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http://purl.uniprot.org/citations/36922513http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/36922513http://www.w3.org/2000/01/rdf-schema#comment"Disruption of brain-expressed G protein-coupled receptor-10 (GPR10) causes obesity in animals. Here, we identify multiple rare variants in GPR10 in people with severe obesity and in normal weight controls. These variants impair ligand binding and G protein-dependent signalling in cells. Transgenic mice harbouring a loss of function GPR10 variant found in an individual with obesity, gain excessive weight due to decreased energy expenditure rather than increased food intake. This evidence supports a role for GPR10 in human energy homeostasis. Therapeutic targeting of GPR10 may represent an effective weight-loss strategy."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.org/dc/terms/identifier"doi:10.1038/s41467-023-36966-3"xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Froguel P."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Arslan M."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Bonnefond A."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Saeed S."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Luckman S.M."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Barroso I."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Adamson A."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Talbot F."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Farooqi I.S."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Keogh J.M."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Yeo G.S.H."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Ayinampudi V."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Bechtold D.A."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Mendes de Oliveira E."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Mokrosinski J."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Henning E."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Lawler K."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Feetham C.H."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/author"Humphreys N."xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/date"2023"xsd:gYear
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/name"Nat Commun"xsd:string
http://purl.uniprot.org/citations/36922513http://purl.uniprot.org/core/pages"1450"xsd:string