http://purl.uniprot.org/citations/36922513 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/36922513 | http://www.w3.org/2000/01/rdf-schema#comment | "Disruption of brain-expressed G protein-coupled receptor-10 (GPR10) causes obesity in animals. Here, we identify multiple rare variants in GPR10 in people with severe obesity and in normal weight controls. These variants impair ligand binding and G protein-dependent signalling in cells. Transgenic mice harbouring a loss of function GPR10 variant found in an individual with obesity, gain excessive weight due to decreased energy expenditure rather than increased food intake. This evidence supports a role for GPR10 in human energy homeostasis. Therapeutic targeting of GPR10 may represent an effective weight-loss strategy."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-36966-3"xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Froguel P."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Arslan M."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Bonnefond A."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Saeed S."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Luckman S.M."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Barroso I."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Adamson A."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Talbot F."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Farooqi I.S."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Keogh J.M."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Yeo G.S.H."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Ayinampudi V."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Bechtold D.A."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Mendes de Oliveira E."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Mokrosinski J."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Henning E."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Lawler K."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Feetham C.H."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/author | "Humphreys N."xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
http://purl.uniprot.org/citations/36922513 | http://purl.uniprot.org/core/pages | "1450"xsd:string |