| http://purl.uniprot.org/citations/36924892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36924892 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies have identified a unique Treg population, which expresses the Th17 characteristic transcription factor RORγt. These RORγt+ Tregs possess enhanced immunosuppressive capacity, which endows them with great therapeutic potential. However, as a caveat, they are also capable of secreting pro-inflammatory IL-17A. Since the sum function of RORγt+ Tregs in glomerulonephritis (GN) remains unknown, we studied the effects of their absence. Purified CD4+ T cell populations, containing or lacking RORγt+ Tregs, were transferred into immunocompromised RAG1 knockout mice and the nephrotoxic nephritis model of GN was induced. Absence of RORγt+ Tregs significantly aggravated kidney injury, demonstrating overall kidney-protective properties. Analyses of immune responses showed that RORγt+ Tregs were broadly immunosuppressive with no preference for a particular type of T cell response. Further characterization revealed a distinct functional and transcriptional profile, including enhanced production of IL-10. Expression of the chemokine receptor CCR6 marked a particularly potent subset, whose absence significantly worsened GN. As an underlying mechanism, we found that chemokine CCL20 acting through receptor CCR6 signaling mediated expansion and activation of RORγt+ Tregs. Finally, we also detected an increase of CCR6+ Tregs in kidney biopsies, as well as enhanced secretion of chemokine CCL20 in 21 patients with anti-neutrophil cytoplasmic antibody associated GN compared to that of 31 healthy living donors, indicating clinical relevance. Thus, our data characterize RORγt+ Tregs as anti-inflammatory mediators of GN and identify them as promising target for Treg directed therapies."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.kint.2023.02.027"xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Huber T.B."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Indenbirken D."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Panzer U."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Steinmetz O.M."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Paust H.J."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Kluger M.A."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Krebs C.F."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Puelles V.G."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Nosko A."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Ramcke T."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Hagenstein J."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Herrnstadt G.R."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Melderis S."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Warkotsch M.T."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Wong M.N."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Niehus C.B."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Ehnold L.I."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Jauch-Speer S.L."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Feindt F.C."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/author | "Sivayoganathan V."xsd:string |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36924892 | http://purl.uniprot.org/core/name | "Kidney Int"xsd:string |