| http://purl.uniprot.org/citations/36930708 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36930708 | http://www.w3.org/2000/01/rdf-schema#comment | "The interleukin-6 (IL-6) family cytokines signal through gp130 receptor homodimerization or heterodimerization with a second signaling receptor and play crucial roles in various cellular processes. We determined cryo-electron microscopy structures of five signaling complexes of this family, containing full receptor ectodomains bound to their respective ligands ciliary neurotrophic factor, cardiotrophin-like cytokine factor 1 (CLCF1), leukemia inhibitory factor, IL-27, and IL-6. Our structures collectively reveal similarities and differences in the assembly of these complexes. The acute bends at both signaling receptors in all complexes bring the membrane-proximal domains to a ~30 angstrom range but with distinct distances and orientations. We also reveal how CLCF1 engages its secretion chaperone cytokine receptor-like factor 1. Our data provide valuable insights for therapeutically targeting gp130-mediated signaling."xsd:string |
| http://purl.uniprot.org/citations/36930708 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.ade4395"xsd:string |
| http://purl.uniprot.org/citations/36930708 | http://purl.uniprot.org/core/author | "Cao J."xsd:string |
| http://purl.uniprot.org/citations/36930708 | http://purl.uniprot.org/core/author | "Franklin M.C."xsd:string |
| http://purl.uniprot.org/citations/36930708 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/36930708 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/36930708 | http://purl.uniprot.org/core/author | "Olson W.C."xsd:string |
| http://purl.uniprot.org/citations/36930708 | http://purl.uniprot.org/core/author | "Stevis P.E."xsd:string |
| http://purl.uniprot.org/citations/36930708 | http://purl.uniprot.org/core/author | "Murphy A.J."xsd:string |
| http://purl.uniprot.org/citations/36930708 | http://purl.uniprot.org/core/author | "Yancopoulos G.D."xsd:string |
| http://purl.uniprot.org/citations/36930708 | http://purl.uniprot.org/core/author | "Saotome K."xsd:string |
| http://purl.uniprot.org/citations/36930708 | http://purl.uniprot.org/core/author | "Sleeman M.W."xsd:string |
| http://purl.uniprot.org/citations/36930708 | http://purl.uniprot.org/core/author | "Haxhinasto S."xsd:string |
| http://purl.uniprot.org/citations/36930708 | http://purl.uniprot.org/core/author | "Glatman Zaretsky A."xsd:string |
| http://purl.uniprot.org/citations/36930708 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36930708 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/36930708 | http://purl.uniprot.org/core/pages | "eade4395"xsd:string |
| http://purl.uniprot.org/citations/36930708 | http://purl.uniprot.org/core/title | "Structural insights into the assembly of gp130 family cytokine signaling complexes."xsd:string |
| http://purl.uniprot.org/citations/36930708 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/36930708 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36930708 |
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| http://purl.uniprot.org/uniprot/#_P42702-mappedCitation-36930708 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36930708 |