| http://purl.uniprot.org/citations/36944026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36944026 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of this study was to examine the effect of diabetes and the diabetogenic TBC1D4 variant on kidney function in Greenland in a population-based setting. Health survey data and TBC1D4 genotypes from 5,336 Greenlanders were used to estimate odds ratios (ORs) of albuminuria (>30 mg/g creatinine) and chronic kidney disease (CKD, eGFR <60 ml/min/1.73m2), comparing individuals with and without diabetes, including the effect of TBC1D4 variant. Of the 3,909 participants with complete data, 9.3% had diabetes. Albuminuria was found in 27.6% and 9.5% and CKD was found in 10.8% and 6.3% among those with and without diabetes, respectively. Diabetes was cross-sectionally associated with an increased risk of albuminuria (OR (95% CI) = 2.37 (1.69,3.33); p < 0.001) and the TBC1D4 variant protected against albuminuria (OR (95% CI) = 0.44 (0.22,0.90); p = 0.02) in a multivariable model. Neither diabetes nor the TBC1D4 variant significantly associated with CKD. The presence/absence of diabetes did not predict changes in eGFR and UACR in longitudinal analyses. Diabetes conferred an increased risk of albuminuria, and the TBC1D4 variant was associated with a decreased risk of albuminuria, but neither was associated with CKD. The potential renoprotective association of the TBC1D4 variant on albuminuria calls for further studies."xsd:string |
| http://purl.uniprot.org/citations/36944026 | http://purl.org/dc/terms/identifier | "doi:10.1080/22423982.2023.2191406"xsd:string |
| http://purl.uniprot.org/citations/36944026 | http://purl.uniprot.org/core/author | "Hansen T."xsd:string |
| http://purl.uniprot.org/citations/36944026 | http://purl.uniprot.org/core/author | "Bjerregaard P."xsd:string |
| http://purl.uniprot.org/citations/36944026 | http://purl.uniprot.org/core/author | "Grarup N."xsd:string |
| http://purl.uniprot.org/citations/36944026 | http://purl.uniprot.org/core/author | "Larsen C.V.L."xsd:string |
| http://purl.uniprot.org/citations/36944026 | http://purl.uniprot.org/core/author | "Jorgensen M.E."xsd:string |
| http://purl.uniprot.org/citations/36944026 | http://purl.uniprot.org/core/author | "Rossing P."xsd:string |
| http://purl.uniprot.org/citations/36944026 | http://purl.uniprot.org/core/author | "Pedersen M.L."xsd:string |
| http://purl.uniprot.org/citations/36944026 | http://purl.uniprot.org/core/author | "Overvad M."xsd:string |
| http://purl.uniprot.org/citations/36944026 | http://purl.uniprot.org/core/author | "Diaz L.J."xsd:string |
| http://purl.uniprot.org/citations/36944026 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36944026 | http://purl.uniprot.org/core/name | "Int J Circumpolar Health"xsd:string |
| http://purl.uniprot.org/citations/36944026 | http://purl.uniprot.org/core/pages | "2191406"xsd:string |
| http://purl.uniprot.org/citations/36944026 | http://purl.uniprot.org/core/title | "The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland."xsd:string |
| http://purl.uniprot.org/citations/36944026 | http://purl.uniprot.org/core/volume | "82"xsd:string |
| http://purl.uniprot.org/citations/36944026 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36944026 |
| http://purl.uniprot.org/citations/36944026 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36944026 |
| http://purl.uniprot.org/uniprot/#_O60343-mappedCitation-36944026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36944026 |
| http://purl.uniprot.org/uniprot/O60343 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36944026 |