| http://purl.uniprot.org/citations/36948206 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36948206 | http://www.w3.org/2000/01/rdf-schema#comment | "Pathogenic α-synuclein and tau are critical drivers of neurodegeneration, and their mutations cause neuronal loss in patients. Whether the underlying preferential neuronal vulnerability is a cell-type-intrinsic property or a consequence of increased expression levels remains elusive. Here, we explore cell-type-specific α-synuclein and tau expression in human brain datasets and use deep phenotyping as well as brain-wide single-cell RNA sequencing of >200 live neuron types in fruit flies to determine which cellular environments react most to α-synuclein or tau toxicity. We detect phenotypic and transcriptomic evidence of differential neuronal vulnerability independent of α-synuclein or tau expression levels. Comparing vulnerable with resilient neurons in Drosophila enabled us to predict numerous human neuron subtypes with increased intrinsic susceptibility to pathogenic α-synuclein or tau. By uncovering synapse- and Ca2+ homeostasis-related genes as tau toxicity modifiers, our work paves the way to leverage neuronal identity to uncover modifiers of neurodegeneration-associated toxic proteins."xsd:string |
| http://purl.uniprot.org/citations/36948206 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2023.02.033"xsd:string |
| http://purl.uniprot.org/citations/36948206 | http://purl.uniprot.org/core/author | "Singh J."xsd:string |
| http://purl.uniprot.org/citations/36948206 | http://purl.uniprot.org/core/author | "Verstreken P."xsd:string |
| http://purl.uniprot.org/citations/36948206 | http://purl.uniprot.org/core/author | "Nachman E."xsd:string |
| http://purl.uniprot.org/citations/36948206 | http://purl.uniprot.org/core/author | "Aerts S."xsd:string |
| http://purl.uniprot.org/citations/36948206 | http://purl.uniprot.org/core/author | "Swerts J."xsd:string |
| http://purl.uniprot.org/citations/36948206 | http://purl.uniprot.org/core/author | "Kuenen S."xsd:string |
| http://purl.uniprot.org/citations/36948206 | http://purl.uniprot.org/core/author | "Schoovaerts N."xsd:string |
| http://purl.uniprot.org/citations/36948206 | http://purl.uniprot.org/core/author | "Janssens J."xsd:string |
| http://purl.uniprot.org/citations/36948206 | http://purl.uniprot.org/core/author | "Calatayud C."xsd:string |
| http://purl.uniprot.org/citations/36948206 | http://purl.uniprot.org/core/author | "Praschberger R."xsd:string |
| http://purl.uniprot.org/citations/36948206 | http://purl.uniprot.org/core/author | "Kaempf N."xsd:string |
| http://purl.uniprot.org/citations/36948206 | http://purl.uniprot.org/core/author | "Poovathingal S."xsd:string |
| http://purl.uniprot.org/citations/36948206 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36948206 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/36948206 | http://purl.uniprot.org/core/pages | "1577-1590.e11"xsd:string |
| http://purl.uniprot.org/citations/36948206 | http://purl.uniprot.org/core/title | "Neuronal identity defines alpha-synuclein and tau toxicity."xsd:string |
| http://purl.uniprot.org/citations/36948206 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/36948206 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36948206 |
| http://purl.uniprot.org/citations/36948206 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36948206 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DHA1-mappedCitation-36948206 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36948206 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFJ4-mappedCitation-36948206 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36948206 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHR4-mappedCitation-36948206 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36948206 |