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http://purl.uniprot.org/citations/36949500http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/36949500http://www.w3.org/2000/01/rdf-schema#comment"

Background

Our study aims to investigate the role and mechanism of circular RNA_0002715 (circ_0002715) in osteoarthritis (OA) progression.

Methods

IL-1β-induced CHON-001 cells were used to mimic OA cell model. Circ_0002715, microRNA (miR)-127-5p and Latexin (LXN) expression was detected by quantitative real-time PCR. Cell functions were determined by MTT assay, flow cytometry and ELISA assay. Protein expression was examined by western blot.

Results

Circ_0002715 was highly expressed in OA cartilage tissues. Circ_0002715 silencing inhibited inflammation, apoptosis, and ECM degradation in IL-1β-interfered CHON-001 cells. Circ_0002715 could sponge miR-127-5p, and miR-127-5p could target LXN. The effect of circ_0002715 down-regulation on chondrocyte injury was partially restored by miR-127-5p inhibitor. MiR-127-5p could suppress chondrocyte injury by inhibiting LXN expression.

Conclusion

Circ_0002715 might be a new therapeutic target for OA, which regulated miR-127-5p/LXN axis to promote IL-1β-induced chondrocyte injury."xsd:string
http://purl.uniprot.org/citations/36949500http://purl.org/dc/terms/identifier"doi:10.1186/s13018-023-03638-3"xsd:string
http://purl.uniprot.org/citations/36949500http://purl.uniprot.org/core/author"Huang Y."xsd:string
http://purl.uniprot.org/citations/36949500http://purl.uniprot.org/core/author"Liu H."xsd:string
http://purl.uniprot.org/citations/36949500http://purl.uniprot.org/core/author"Lei M."xsd:string
http://purl.uniprot.org/citations/36949500http://purl.uniprot.org/core/author"Zhao H."xsd:string
http://purl.uniprot.org/citations/36949500http://purl.uniprot.org/core/date"2023"xsd:gYear
http://purl.uniprot.org/citations/36949500http://purl.uniprot.org/core/name"J Orthop Surg Res"xsd:string
http://purl.uniprot.org/citations/36949500http://purl.uniprot.org/core/pages"230"xsd:string
http://purl.uniprot.org/citations/36949500http://purl.uniprot.org/core/title"Circ_0002715 promotes the development of osteoarthritis through regulating LXN by sponging miR-127-5p."xsd:string
http://purl.uniprot.org/citations/36949500http://purl.uniprot.org/core/volume"18"xsd:string
http://purl.uniprot.org/citations/36949500http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/36949500
http://purl.uniprot.org/citations/36949500http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/36949500
http://purl.uniprot.org/uniprot/#_Q9BS40-mappedCitation-36949500http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/36949500
http://purl.uniprot.org/uniprot/Q9BS40http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/36949500