| http://purl.uniprot.org/citations/36972230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36972230 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-12p40 plays an important role in F. tularensis Live Vaccine Strain (LVS) clearance that is independent of its functions as a part of the heterodimeric cytokines IL-12p70 or IL-23. In contrast to WT, p35, or p19 knockout (KO) mice, p40 KO mice infected with LVS develop a chronic infection that does not resolve. Here, we further evaluated the role of IL-12p40 in F. tularensis clearance. Despite reduced IFN-γ production, primed splenocytes from p40 KO and p35 KO mice appeared functionally similar to those from WT mice during in vitro co-culture assays of intramacrophage bacterial growth control. Gene expression analysis revealed a subset of genes that were upregulated in re-stimulated WT and p35 KO splenocytes, but not p40 KO splenocytes, and thus are candidates for involvement in F. tularensis clearance. To directly evaluate a potential mechanism for p40 in F. tularensis clearance, we reconstituted protein levels in LVS-infected p40 KO mice using either intermittent injections of p40 homodimer (p80) or treatment with a p40-producing lentivirus construct. Although both delivery strategies yielded readily detectable levels of p40 in sera and spleens, neither treatment had a measurable impact on LVS clearance by p40 KO mice. Taken together, these studies demonstrate that clearance of F. tularensis infection depends on p40, but p40 monomers and/or dimers alone are not sufficient."xsd:string |
| http://purl.uniprot.org/citations/36972230 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0283161"xsd:string |
| http://purl.uniprot.org/citations/36972230 | http://purl.uniprot.org/core/author | "Swoboda J."xsd:string |
| http://purl.uniprot.org/citations/36972230 | http://purl.uniprot.org/core/author | "Elkins K.L."xsd:string |
| http://purl.uniprot.org/citations/36972230 | http://purl.uniprot.org/core/author | "De Pascalis R."xsd:string |
| http://purl.uniprot.org/citations/36972230 | http://purl.uniprot.org/core/author | "Mittereder L.R."xsd:string |
| http://purl.uniprot.org/citations/36972230 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36972230 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/36972230 | http://purl.uniprot.org/core/pages | "e0283161"xsd:string |
| http://purl.uniprot.org/citations/36972230 | http://purl.uniprot.org/core/title | "IL-12p40 is essential but not sufficient for Francisella tularensis LVS clearance in chronically infected mice."xsd:string |
| http://purl.uniprot.org/citations/36972230 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/36972230 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36972230 |
| http://purl.uniprot.org/citations/36972230 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36972230 |
| http://purl.uniprot.org/uniprot/#_F8WI71-mappedCitation-36972230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36972230 |
| http://purl.uniprot.org/uniprot/#_Q3ZAX5-mappedCitation-36972230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36972230 |
| http://purl.uniprot.org/uniprot/#_P43431-mappedCitation-36972230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36972230 |
| http://purl.uniprot.org/uniprot/#_P43432-mappedCitation-36972230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36972230 |
| http://purl.uniprot.org/uniprot/#_Q549G3-mappedCitation-36972230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36972230 |
| http://purl.uniprot.org/uniprot/#_Q9QUT1-mappedCitation-36972230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36972230 |
| http://purl.uniprot.org/uniprot/P43431 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36972230 |
| http://purl.uniprot.org/uniprot/Q549G3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36972230 |
| http://purl.uniprot.org/uniprot/P43432 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36972230 |
| http://purl.uniprot.org/uniprot/Q3ZAX5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36972230 |
| http://purl.uniprot.org/uniprot/Q9QUT1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36972230 |