| http://purl.uniprot.org/citations/36973294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36973294 | http://www.w3.org/2000/01/rdf-schema#comment | "The functions of the influenza virus neuraminidase has been well documented but those of the mammalian neuraminidases remain less explored. Here, we characterize the role of neuraminidase 1 (NEU1) in unilateral ureteral obstruction (UUO) and folic acid (FA)-induced renal fibrosis mouse models. We find that NEU1 is significantly upregulated in the fibrotic kidneys of patients and mice. Functionally, tubular epithelial cell-specific NEU1 knockout inhibits epithelial-to-mesenchymal transition, inflammatory cytokines production, and collagen deposition in mice. Conversely, NEU1 overexpression exacerbates progressive renal fibrosis. Mechanistically, NEU1 interacts with TGFβ type I receptor ALK5 at the 160-200aa region and stabilizes ALK5 leading to SMAD2/3 activation. Salvianolic acid B, a component of Salvia miltiorrhiza, is found to strongly bind to NEU1 and effectively protect mice from renal fibrosis in a NEU1-dependent manner. Collectively, this study characterizes a promotor role for NEU1 in renal fibrosis and suggests a potential avenue of targeting NEU1 to treat kidney diseases."xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-37450-8"xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/author | "Li P."xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/author | "Zhang J.Y."xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/author | "Liu K."xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/author | "Ma G."xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/author | "Jin S.J."xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/author | "Yu X.Y."xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/author | "Shi N."xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/author | "Chen Q.Q."xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/author | "Wei T.T."xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/author | "Qi L.W."xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/author | "Xie H.M."xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/pages | "1713"xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/title | "Neuraminidase 1 promotes renal fibrosis development in male mice."xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/36973294 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36973294 |
| http://purl.uniprot.org/citations/36973294 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36973294 |
| http://purl.uniprot.org/uniprot/#_Q3UL64-mappedCitation-36973294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36973294 |