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http://purl.uniprot.org/citations/36990072http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/36990072http://www.w3.org/2000/01/rdf-schema#comment"

Background

Our previous studies have shown that the basic helix-loop-helix family member e40 (Bhlhe40) plays a critical role in regulating calcification and senescence of vascular smooth muscle cells induced by high glucose. In this study, we determined the association between serum Bhlhe40 levels and subclinical atherosclerosis in patients with type 2 diabetes mellitus (T2DM).

Methods

247 patients with T2DM were included in this cross-sectional study between June 2021 and July 2022. The presence of subclinical atherosclerosis was evaluated by carotid ultrasonography. Serum Bhlhe40 concentrations were measured with an ELISA kit.

Results

Serum Bhlhe40 levels were remarkably higher in the subclinical atherosclerosis group than in the subjects without subclinical atherosclerosis (p < 0.001). Correlation analysis showed a positive correlation between serum Bhlhe40 and carotid intima-media thickness (C-IMT) (r = 0.155, p = 0.015). The optimal threshold of serum Bhlhe40 > 5.67 ng/mL had an area under the ROC curve (AUC) was 0.709 (p < 0.001). In addition, serum Bhlhe40 levels were associated with the prevalence of subclinical atherosclerosis (OR: 1.790, 95% CI: 1.414-2.266, p < 0.001).

Conclusion

Serum Bhlhe40 levels were significantly higher in T2DM subjects with subclinical atherosclerosis and positively associated with C-IMT."xsd:string
http://purl.uniprot.org/citations/36990072http://purl.org/dc/terms/identifier"doi:10.1177/14791641231169246"xsd:string
http://purl.uniprot.org/citations/36990072http://purl.uniprot.org/core/author"Li S."xsd:string
http://purl.uniprot.org/citations/36990072http://purl.uniprot.org/core/author"Xu H."xsd:string
http://purl.uniprot.org/citations/36990072http://purl.uniprot.org/core/author"Liu Y.S."xsd:string
http://purl.uniprot.org/citations/36990072http://purl.uniprot.org/core/author"Xiang Q.Y."xsd:string
http://purl.uniprot.org/citations/36990072http://purl.uniprot.org/core/date"2023"xsd:gYear
http://purl.uniprot.org/citations/36990072http://purl.uniprot.org/core/name"Diab Vasc Dis Res"xsd:string
http://purl.uniprot.org/citations/36990072http://purl.uniprot.org/core/pages"14791641231169246"xsd:string
http://purl.uniprot.org/citations/36990072http://purl.uniprot.org/core/title"High serum Bhlhe40 levels are associated with subclinical atherosclerosis in patients with type 2 diabetes mellitus: A cross-sectional study."xsd:string
http://purl.uniprot.org/citations/36990072http://purl.uniprot.org/core/volume"20"xsd:string
http://purl.uniprot.org/citations/36990072http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/36990072
http://purl.uniprot.org/citations/36990072http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/36990072
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http://purl.uniprot.org/uniprot/O14503http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/36990072
http://purl.uniprot.org/uniprot/Q6IB83http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/36990072