| http://purl.uniprot.org/citations/36990128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36990128 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia-regulated proximal tubular epithelial cells (PTCs) G2/M phase arrest/delay was involved in production of renal tubulointerstitial fibrosis (TIF). TIF is a common pathological manifestation of progression in patients with chronic kidney disease (CKD), and is often accompanied by lipid accumulation in renal tubules. However, cause-effect relationship between hypoxia-inducible lipid droplet-associated protein (Hilpda), lipid accumulation, G2/M phase arrest/delay and TIF remains unclear. Here we found that overexpression of Hilpda downregulated adipose triglyceride lipase (ATGL) promoted triglyceride overload in the form of lipid accumulation, leading to defective fatty acid β-oxidation (FAO), ATP depletion in a human PTC cell line (HK-2) under hypoxia and in mice kidney tissue treated with unilateral ureteral obstruction (UUO) and unilateral ischemia-reperfusion injury (UIRI). Hilpda-induced lipid accumulation caused mitochondrial dysfunction, enhanced expression of profibrogenic factors TGF-β1, α-SMA and Collagen I elevation, and reduced expression of G2/M phase-associated gene CDK1, as well as increased CyclinB1/D1 ratio, resulted in G2/M phase arrest/delay and profibrogenic phenotypes. Hilpda deficiency in HK-2 cell and kidney of mice with UUO had sustained expression of ATGL and CDK1 and reduced expression of TGF-β1, Collagen I and CyclinB1/D1 ratio, resulting in the amelioration of lipid accumulation and G2/M arrest/delay and subsequent TIF. Expression of Hilpda correlated with lipid accumulation, was positively associated with tubulointerstitial fibrosis in tissue samples from patients with CKD. Our findings suggest that Hilpda deranges fatty acid metabolism in PTCs, which leads to G2/M phase arrest/delay and upregulation of profibrogenic factors, and consequently promote TIF which possibly underlie pathogenesis of CKD."xsd:string |
| http://purl.uniprot.org/citations/36990128 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbadis.2023.166701"xsd:string |
| http://purl.uniprot.org/citations/36990128 | http://purl.uniprot.org/core/author | "He Z."xsd:string |
| http://purl.uniprot.org/citations/36990128 | http://purl.uniprot.org/core/author | "Jia R."xsd:string |
| http://purl.uniprot.org/citations/36990128 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/36990128 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/36990128 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/36990128 | http://purl.uniprot.org/core/author | "Sun S."xsd:string |
| http://purl.uniprot.org/citations/36990128 | http://purl.uniprot.org/core/author | "Qu Y."xsd:string |
| http://purl.uniprot.org/citations/36990128 | http://purl.uniprot.org/core/author | "Lv Z."xsd:string |
| http://purl.uniprot.org/citations/36990128 | http://purl.uniprot.org/core/author | "Tai F."xsd:string |
| http://purl.uniprot.org/citations/36990128 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36990128 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta Mol Basis Dis"xsd:string |
| http://purl.uniprot.org/citations/36990128 | http://purl.uniprot.org/core/pages | "166701"xsd:string |
| http://purl.uniprot.org/citations/36990128 | http://purl.uniprot.org/core/title | "Downregulation of fatty acid oxidation led by Hilpda increases G2/M arrest/delay-induced kidney fibrosis."xsd:string |
| http://purl.uniprot.org/citations/36990128 | http://purl.uniprot.org/core/volume | "1869"xsd:string |
| http://purl.uniprot.org/citations/36990128 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36990128 |
| http://purl.uniprot.org/citations/36990128 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36990128 |
| http://purl.uniprot.org/uniprot/#_Q9JLS0-mappedCitation-36990128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36990128 |
| http://purl.uniprot.org/uniprot/#_Q9Y5L2-mappedCitation-36990128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36990128 |
| http://purl.uniprot.org/uniprot/Q9JLS0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36990128 |
| http://purl.uniprot.org/uniprot/Q9Y5L2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36990128 |