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http://purl.uniprot.org/citations/36993956http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/36993956http://www.w3.org/2000/01/rdf-schema#comment"

Introduction

Most T lymphocytes, including regulatory T cells, express the CD27 costimulatory receptor in steady state conditions. There is evidence that CD27 engagement on conventional T lymphocytes favors the development of Th1 and cytotoxic responses in mice and humans, but the impact on the regulatory lineage is unknown.

Methods

In this report, we examined the effect of constitutive CD27 engagement on both regulatory and conventional CD4+ T cells in vivo, in the absence of intentional antigenic stimulation.

Results

Our data show that both T cell subsets polarize into type 1 Tconvs or Tregs, characterized by cell activation, cytokine production, response to IFN-γ and CXCR3-dependent migration to inflammatory sites. Transfer experiments suggest that CD27 engagement triggers Treg activation in a cell autonomous fashion.

Conclusion

We conclude that CD27 may regulate the development of Th1 immunity in peripheral tissues as well as the subsequent switch of the effector response into long-term memory."xsd:string
http://purl.uniprot.org/citations/36993956http://purl.org/dc/terms/identifier"doi:10.3389/fimmu.2023.1023064"xsd:string
http://purl.uniprot.org/citations/36993956http://purl.uniprot.org/core/author"Moser M."xsd:string
http://purl.uniprot.org/citations/36993956http://purl.uniprot.org/core/author"Yagita H."xsd:string
http://purl.uniprot.org/citations/36993956http://purl.uniprot.org/core/author"Goriely S."xsd:string
http://purl.uniprot.org/citations/36993956http://purl.uniprot.org/core/author"Azouz A."xsd:string
http://purl.uniprot.org/citations/36993956http://purl.uniprot.org/core/author"Leo O."xsd:string
http://purl.uniprot.org/citations/36993956http://purl.uniprot.org/core/author"Oldenhove G."xsd:string
http://purl.uniprot.org/citations/36993956http://purl.uniprot.org/core/author"Acolty V."xsd:string
http://purl.uniprot.org/citations/36993956http://purl.uniprot.org/core/author"Bowakim-Anta N."xsd:string
http://purl.uniprot.org/citations/36993956http://purl.uniprot.org/core/date"2023"xsd:gYear
http://purl.uniprot.org/citations/36993956http://purl.uniprot.org/core/name"Front Immunol"xsd:string
http://purl.uniprot.org/citations/36993956http://purl.uniprot.org/core/pages"1023064"xsd:string
http://purl.uniprot.org/citations/36993956http://purl.uniprot.org/core/title"Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs."xsd:string
http://purl.uniprot.org/citations/36993956http://purl.uniprot.org/core/volume"14"xsd:string
http://purl.uniprot.org/citations/36993956http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/36993956
http://purl.uniprot.org/citations/36993956http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/36993956
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http://purl.uniprot.org/uniprot/#_A0A3Q4EI60-mappedCitation-36993956http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/36993956
http://purl.uniprot.org/uniprot/#_A0A3Q4L2R0-mappedCitation-36993956http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/36993956
http://purl.uniprot.org/uniprot/#_B7ZW87-mappedCitation-36993956http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/36993956
http://purl.uniprot.org/uniprot/#_F6VSW9-mappedCitation-36993956http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/36993956
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