| http://purl.uniprot.org/citations/37000885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37000885 | http://www.w3.org/2000/01/rdf-schema#comment | "The metalloproteases meprin α and meprin β are highly expressed in the healthy gut but significantly decreased in inflammatory bowel disease, implicating a protective role in mucosal homeostasis. In the colon, meprin α and meprin β form covalently linked heterodimers tethering meprin α to the plasma membrane, therefore presenting dual proteolytic activity in a unique enzyme complex. To unravel its function, we applied N-terminomics and identified galectin-3 as the major intestinal substrate for meprin α/β heterodimers. Galectin-3-deficient and meprin α/β double knockout mice show similar alterations in their microbiome in comparison to wild-type mice. We further demonstrate that meprin α/β heterodimers differentially process galectin-3 upon bacterial infection, in germ-free, conventionally housed (specific pathogen-free), or wildling mice, which in turn regulates the bacterial agglutination properties of galectin-3. Thus, the constitutive cleavage of galectin-3 by meprin α/β heterodimers may play a key role in colon host-microbiome homeostasis."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.adf4055"xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Zhao B."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Rosenstiel P."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Fickenscher H."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Becker-Pauly C."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Koudelka T."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Tholey A."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Theilig F."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Scharfenberg F."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Tran F."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Hansson G.C."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Starkl P."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Rosshart S.P."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Nystrom E.E.L."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Armbrust F."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Dahlke E."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Radhouani M."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Bulck C."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Andresen G."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Mannbar-Frahm M."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Schrell F."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/author | "Vervaeke A."xsd:string |
| http://purl.uniprot.org/citations/37000885 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |