| http://purl.uniprot.org/citations/37001519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37001519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37001519 | http://www.w3.org/2000/01/rdf-schema#comment | "Intracellular sensing of lipopolysaccharide (LPS) by murine caspase-11 or human caspase-4 initiates a protease cascade, termed the non-canonical inflammasome, that results in gasdermin D (GSDMD) processing and subsequent NLRP3 inflammasome activation. In an effort aimed at identifying additional sensors for intracellular LPS by biochemical screening, we identified the nuclear orphan receptor Nur77 as an LPS-binding protein in macrophage lysates. Nr4a1-/- macrophages exhibited impaired activation of the NLRP3 inflammasome, but not caspase-11, in response to LPS. Biochemical mapping revealed that Nur77 bound LPS directly through a domain in its C terminus. Yeast two-hybrid assays identified NLRP3 as a binding partner for Nur77. The association between Nur77 and NLRP3 required the presence of LPS and dsDNA. The source of dsDNA was the mitochondria, requiring the formation of gasdermin-D pores. In vivo, Nur77 deficiency ameliorated host response to endotoxins. Thus, Nur77 functions as an intracellular LPS sensor, binding mitochondrial DNA and LPS to activate the non-canonical NLRP3 inflammasome."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2023.03.003"xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2023.03.003"xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Qian Y."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Qian Y."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Qin X."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Qin X."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Zhu F."xsd:string |
| http://purl.uniprot.org/citations/37001519 | http://purl.uniprot.org/core/author | "Zhu F."xsd:string |