| http://purl.uniprot.org/citations/37013690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37013690 | http://www.w3.org/2000/01/rdf-schema#comment | "Fas ligand is increased in several immune-mediated diseases, including acute graft-versus-host disease, a donor cell-mediated disorder post-hematopoietic stem cell transplantation. In this disease, Fas ligand is involved in T-cell-mediated damage to host tissues. However, the role of its expression on donor non-T cells has, so far, never been addressed. Using a well-established CD4- and CD8-mediated graft-versus-host disease murine model, we found that precocious gut damage and mice mortality are increased with a graft of donor T- and B-depleted bone marrow cells devoid of Fas ligand as compared with their wild-type counterparts. Interestingly, serum levels of both soluble Fas ligand and IL-18 are drastically reduced in the recipients of Fas ligand-deficient grafts, indicating that soluble Fas ligand stems from donor bone marrow-derived cells. In addition, the correlation between the concentrations of these 2 cytokines suggests that IL-18 production arises through a soluble Fas ligand-driven mechanism. These data highlight the importance of Fas ligand-dependent production in IL-18 production and in mitigating acute graft-versus-host disease. Overall, our data reveal the functional duality of Fas ligand according to its source."xsd:string |
| http://purl.uniprot.org/citations/37013690 | http://purl.org/dc/terms/identifier | "doi:10.1093/jleuko/qiad040"xsd:string |
| http://purl.uniprot.org/citations/37013690 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/37013690 | http://purl.uniprot.org/core/author | "Garcia A."xsd:string |
| http://purl.uniprot.org/citations/37013690 | http://purl.uniprot.org/core/author | "Parietti V."xsd:string |
| http://purl.uniprot.org/citations/37013690 | http://purl.uniprot.org/core/author | "Socie G."xsd:string |
| http://purl.uniprot.org/citations/37013690 | http://purl.uniprot.org/core/author | "Legembre P."xsd:string |
| http://purl.uniprot.org/citations/37013690 | http://purl.uniprot.org/core/author | "Karray S."xsd:string |
| http://purl.uniprot.org/citations/37013690 | http://purl.uniprot.org/core/author | "Doliger C."xsd:string |
| http://purl.uniprot.org/citations/37013690 | http://purl.uniprot.org/core/author | "Sutra Del Galy A."xsd:string |
| http://purl.uniprot.org/citations/37013690 | http://purl.uniprot.org/core/author | "Bernard-Bloch R."xsd:string |
| http://purl.uniprot.org/citations/37013690 | http://purl.uniprot.org/core/author | "Lebrault E."xsd:string |
| http://purl.uniprot.org/citations/37013690 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37013690 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/37013690 | http://purl.uniprot.org/core/pages | "205-211"xsd:string |
| http://purl.uniprot.org/citations/37013690 | http://purl.uniprot.org/core/title | "Ambivalent role of FasL in murine acute graft-versus-host-disease."xsd:string |
| http://purl.uniprot.org/citations/37013690 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/37013690 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37013690 |
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| http://purl.uniprot.org/uniprot/#_Q99PH8-mappedCitation-37013690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37013690 |