| http://purl.uniprot.org/citations/37014062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37014062 | http://www.w3.org/2000/01/rdf-schema#comment | "In the polarity/protrusion model of growth cone repulsion from UNC-6/netrin, UNC-6 first polarizes the growth cone of the VD motor neuron axon via the UNC-5 receptor, and then regulates protrusion asymmetrically across the growth cone based on this polarity. UNC-6 stimulates protrusion dorsally through the UNC-40/DCC receptor, and inhibits protrusion ventrally through UNC-5, resulting in net dorsal growth. Previous studies showed that UNC-5 inhibits growth cone protrusion via the flavin monooxygenases and potential destabilization of F-actin, and via UNC-33/CRMP and restriction of microtubule plus-end entry into the growth cone. We show that UNC-5 inhibits protrusion through a third mechanism involving TOM-1/tomosyn. A short isoform of TOM-1 inhibited protrusion downstream of UNC-5, and a long isoform had a pro-protrusive role. TOM-1/tomosyn inhibits formation of the SNARE complex. We show that UNC-64/syntaxin is required for growth cone protrusion, consistent with a role of TOM-1 in inhibiting vesicle fusion. Our results are consistent with a model whereby UNC-5 utilizes TOM-1 to inhibit vesicle fusion, resulting in inhibited growth cone protrusion, possibly by preventing the growth cone plasma membrane addition required for protrusion."xsd:string |
| http://purl.uniprot.org/citations/37014062 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.201031"xsd:string |
| http://purl.uniprot.org/citations/37014062 | http://purl.uniprot.org/core/author | "Lundquist E.A."xsd:string |
| http://purl.uniprot.org/citations/37014062 | http://purl.uniprot.org/core/author | "Mahadik S.S."xsd:string |
| http://purl.uniprot.org/citations/37014062 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37014062 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/37014062 | http://purl.uniprot.org/core/pages | "dev201031"xsd:string |
| http://purl.uniprot.org/citations/37014062 | http://purl.uniprot.org/core/title | "TOM-1/tomosyn acts with the UNC-6/netrin receptor UNC-5 to inhibit growth cone protrusion in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/37014062 | http://purl.uniprot.org/core/volume | "150"xsd:string |
| http://purl.uniprot.org/citations/37014062 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37014062 |
| http://purl.uniprot.org/citations/37014062 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37014062 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AWL6-mappedCitation-37014062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37014062 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AR90-mappedCitation-37014062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37014062 |
| http://purl.uniprot.org/uniprot/#_A0A0K3ATN9-mappedCitation-37014062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37014062 |
| http://purl.uniprot.org/uniprot/#_Q14DX2-mappedCitation-37014062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37014062 |
| http://purl.uniprot.org/uniprot/#_A8WFN4-mappedCitation-37014062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37014062 |
| http://purl.uniprot.org/uniprot/#_P34710-mappedCitation-37014062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37014062 |
| http://purl.uniprot.org/uniprot/#_G5EE26-mappedCitation-37014062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37014062 |
| http://purl.uniprot.org/uniprot/#_Q26261-mappedCitation-37014062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37014062 |
| http://purl.uniprot.org/uniprot/#_Q49HI3-mappedCitation-37014062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37014062 |
| http://purl.uniprot.org/uniprot/Q26261 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37014062 |
| http://purl.uniprot.org/uniprot/A0A0K3AWL6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37014062 |
| http://purl.uniprot.org/uniprot/A8WFN4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37014062 |
| http://purl.uniprot.org/uniprot/A0A0K3ATN9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37014062 |