| http://purl.uniprot.org/citations/37037907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37037907 | http://www.w3.org/2000/01/rdf-schema#comment | "Proteasome 26S subunit, non-ATPase 12 (PSMD12) genes have been implicated in several types of malignancies but the role of PSMD12 in pancreatic cancer (PC) remains elusive. Bioinformatics analysis showed that PSMD12 was highly expressed in PC patients and was associated with shorter overall survival. PSMD12 was also shown to be highly expressed in PC tissues and cell lines. Upregulated PSMD12 showed enhanced cell viability, increased colony formation rate and upregulated levels of PCNA and c-Myc, while the inhibition of PSMD12 abated these levels. PSMD12 knockdown promoted cell apoptosis. The results of xenografts in nude mice confirmed that PSMD12 promoted PC tumor growth in vivo. Protein‒protein interaction network and functional enrichment analyses implied that PSMD12 may have a connection with cyclin-dependent kinase inhibitor 3 (CDKN3). Co‑immunoprecipitation and western blot results confirmed that PSMD12 could interact with and abate the ubiquitination level of CDKN3, thus stabilizing the CDKN3 protein. Rescue assays showed that PSMD12 overexpression caused cell proliferation and that knockdown-induced cell apoptosis could be reversed by CDKN3 regulation. This work reveals the essential roles of PSMD12 in the proliferation and apoptosis of PC development. PSMD12 may regulate CDKN3 expression by interacting with and abating the ubiquitination level of CDKN3, thereby participating in the malignant behavior of PC."xsd:string |
| http://purl.uniprot.org/citations/37037907 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41417-023-00609-y"xsd:string |
| http://purl.uniprot.org/citations/37037907 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/37037907 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/37037907 | http://purl.uniprot.org/core/author | "Yuan Y."xsd:string |
| http://purl.uniprot.org/citations/37037907 | http://purl.uniprot.org/core/author | "Zhou W."xsd:string |
| http://purl.uniprot.org/citations/37037907 | http://purl.uniprot.org/core/author | "Meng X."xsd:string |
| http://purl.uniprot.org/citations/37037907 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37037907 | http://purl.uniprot.org/core/name | "Cancer Gene Ther"xsd:string |
| http://purl.uniprot.org/citations/37037907 | http://purl.uniprot.org/core/pages | "1072-1083"xsd:string |
| http://purl.uniprot.org/citations/37037907 | http://purl.uniprot.org/core/title | "PSMD12 interacts with CDKN3 and facilitates pancreatic cancer progression."xsd:string |
| http://purl.uniprot.org/citations/37037907 | http://purl.uniprot.org/core/volume | "30"xsd:string |
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