| http://purl.uniprot.org/citations/37040761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37040761 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon-γ (IFN-γ) is a key cytokine in response to viral or intracellular bacterial infection in mammals. While a number of enhancers are described to promote IFN-γ responses, to the best of our knowledge, no silencers for the Ifng gene have been identified. By examining H3K4me1 histone modification in naive CD4+ T cells within Ifng locus, we identified a silencer (CNS-28) that restrains Ifng expression. Mechanistically, CNS-28 maintains Ifng silence by diminishing enhancer-promoter interactions within Ifng locus in a GATA3-dependent but T-bet-independent manner. Functionally, CNS-28 restrains Ifng transcription in NK cells, CD4+ cells, and CD8+ T cells during both innate and adaptive immune responses. Moreover, CNS-28 deficiency resulted in repressed type 2 responses due to elevated IFN-γ expression, shifting Th1 and Th2 paradigm. Thus, CNS-28 activity ensures immune cell quiescence by cooperating with other regulatory cis elements within the Ifng gene locus to minimize autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/37040761 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2023.03.006"xsd:string |
| http://purl.uniprot.org/citations/37040761 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/37040761 | http://purl.uniprot.org/core/author | "Cao Y."xsd:string |
| http://purl.uniprot.org/citations/37040761 | http://purl.uniprot.org/core/author | "Hu G."xsd:string |
| http://purl.uniprot.org/citations/37040761 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/37040761 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/37040761 | http://purl.uniprot.org/core/author | "Ren G."xsd:string |
| http://purl.uniprot.org/citations/37040761 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/37040761 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/37040761 | http://purl.uniprot.org/core/author | "Wei D."xsd:string |
| http://purl.uniprot.org/citations/37040761 | http://purl.uniprot.org/core/author | "Zhao K."xsd:string |
| http://purl.uniprot.org/citations/37040761 | http://purl.uniprot.org/core/author | "Fang D."xsd:string |
| http://purl.uniprot.org/citations/37040761 | http://purl.uniprot.org/core/author | "Cui K."xsd:string |
| http://purl.uniprot.org/citations/37040761 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37040761 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/37040761 | http://purl.uniprot.org/core/pages | "944-958.e6"xsd:string |
| http://purl.uniprot.org/citations/37040761 | http://purl.uniprot.org/core/title | "Restraint of IFN-gamma expression through a distal silencer CNS-28 for tissue homeostasis."xsd:string |
| http://purl.uniprot.org/citations/37040761 | http://purl.uniprot.org/core/volume | "56"xsd:string |
| http://purl.uniprot.org/citations/37040761 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37040761 |
| http://purl.uniprot.org/citations/37040761 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37040761 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY77-mappedCitation-37040761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37040761 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQ73-mappedCitation-37040761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37040761 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHD4-mappedCitation-37040761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37040761 |