| http://purl.uniprot.org/citations/37041174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37041174 | http://www.w3.org/2000/01/rdf-schema#comment | "Lung mast cells are important in host defense, and excessive proliferation or activation of these cells can cause chronic inflammatory disorders like asthma. Two parallel pathways induced by KIT-stem cell factor (SCF) and FcεRI-immunoglobulin E interactions are critical for the proliferation and activation of mast cells, respectively. Here, we report that mast cell-expressed membrane protein1 (MCEMP1), a lung-specific surface protein, functions as an adaptor for KIT, which promotes SCF-mediated mast cell proliferation. MCEMP1 elicits intracellular signaling through its cytoplasmic immunoreceptor tyrosine-based activation motif and forms a complex with KIT to enhance its autophosphorylation and activation. Consequently, MCEMP1 deficiency impairs SCF-induced peritoneal mast cell proliferation in vitro and lung mast cell expansion in vivo. Mcemp1-deficient mice exhibit reduced airway inflammation and lung impairment in chronic asthma mouse models. This study shows lung-specific MCEMP1 as an adaptor for KIT to facilitate SCF-mediated mast cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-37873-3"xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Kang S."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Kim D."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Seo G.J."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Jung J.U."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Yoo J.S."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Choi Y."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Jung K."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Kwak M.J."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Hong B."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Jiang Z."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Rice L."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Choi Y.J."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Lee S.A."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Foo S.S."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Asosingh K."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Johnson H."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Akbari O."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Amini-Bavil-Olyaee S."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Madden E."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Choi U.Y."xsd:string |
| http://purl.uniprot.org/citations/37041174 | http://purl.uniprot.org/core/author | "Maazi H."xsd:string |