| http://purl.uniprot.org/citations/37052526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37052526 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveConcern exists that medications used to treat patients with systemic juvenile idiopathic arthritis (JIA), particularly interleukin (IL)-1 and IL-6 blocking agents, might be causing adverse drug reactions and lung disease (systemic JIA-LD). Carriage of HLA-DRB1*15 has been reported as a risk factor for adverse drug reactions among patients with systemic JIA. We performed a retrospective chart review to evaluate these factors at our center.MethodsWe reviewed the records of 86 subjects with systemic JIA followed for at least 6 months between 1996 and 2022. HLA typing was performed in 23 of the subjects. We compared characteristics of patients with or without eosinophilia. Among patients with HLA typing, we compared clinical characteristics of subjects with or without DRB1*15 and with or without systemic JIA-LD.ResultsAmong the 23 patients with HLA typing, 74% carried DRB1*15, and 63% of patients without systemic JIA-LD carried DRB1*15. Seven subjects had systemic JIA-LD, all of whom carried DRB1*15. Patients with systemic JIA-LD were younger at the time of diagnosis and more likely to have had macrophage activation syndrome. Exposure to IL-1 and IL-6 blockers was common, occurring in 95% of patients. Eosinophilia occurred in 39% of patients with systemic JIA, often before IL-1 or IL-6 blockade. Eosinophilia was associated with adverse drug reactions and macrophage activation syndrome. There was 1 death, unrelated to active systemic JIA disease.ConclusionCarriage of DRB1*15 was more common in this cohort of patients with systemic JIA than in the general population. Eosinophilia and systemic JIA-LD were more common among patients with severe systemic JIA complicated by macrophage activation syndrome."xsd:string |
| http://purl.uniprot.org/citations/37052526 | http://purl.org/dc/terms/identifier | "doi:10.1002/acr.25132"xsd:string |
| http://purl.uniprot.org/citations/37052526 | http://purl.uniprot.org/core/author | "Binstadt B.A."xsd:string |
| http://purl.uniprot.org/citations/37052526 | http://purl.uniprot.org/core/author | "Mahmud S.A."xsd:string |
| http://purl.uniprot.org/citations/37052526 | http://purl.uniprot.org/core/author | "Hobday P.M."xsd:string |
| http://purl.uniprot.org/citations/37052526 | http://purl.uniprot.org/core/author | "Alfath Z."xsd:string |
| http://purl.uniprot.org/citations/37052526 | http://purl.uniprot.org/core/author | "Langworthy B.W."xsd:string |
| http://purl.uniprot.org/citations/37052526 | http://purl.uniprot.org/core/author | "Lerman A.M."xsd:string |
| http://purl.uniprot.org/citations/37052526 | http://purl.uniprot.org/core/author | "Riskalla M.M."xsd:string |
| http://purl.uniprot.org/citations/37052526 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37052526 | http://purl.uniprot.org/core/name | "Arthritis Care Res (Hoboken)"xsd:string |
| http://purl.uniprot.org/citations/37052526 | http://purl.uniprot.org/core/pages | "2082-2087"xsd:string |
| http://purl.uniprot.org/citations/37052526 | http://purl.uniprot.org/core/title | "HLA-DRB1*15 and Eosinophilia Are Common Among Patients With Systemic Juvenile Idiopathic Arthritis."xsd:string |
| http://purl.uniprot.org/citations/37052526 | http://purl.uniprot.org/core/volume | "75"xsd:string |
| http://purl.uniprot.org/citations/37052526 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37052526 |
| http://purl.uniprot.org/citations/37052526 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37052526 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-37052526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37052526 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-37052526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37052526 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-37052526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37052526 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD60-mappedCitation-37052526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37052526 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD66-mappedCitation-37052526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37052526 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI1-mappedCitation-37052526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37052526 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI3-mappedCitation-37052526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37052526 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WAE5-mappedCitation-37052526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37052526 |