| http://purl.uniprot.org/citations/37052702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37052702 | http://www.w3.org/2000/01/rdf-schema#comment | "Excessive apoptosis of intervertebral disc cells, namely nucleus pulposus (NP) cells, results in decreased cell density and extracellular matrix (ECM) catabolism, hence leading to intervertebral disc degeneration (IVDD). As a cell model in the present study, a commercially available human NP cell line was utilized. Long noncoding RNAs and microRNAs may regulate the proliferation or apoptosis of human NP cells, hence exerting a significant influence on the occurrence of IVDD. KLF3-AS1 was discovered to be abnormally downregulated in IVDD tissues. Overexpression of KLF3-AS1 enhanced NP cell viability, prevented cell apoptosis, boosted ECM synthesis, and lowered MMP-13 and ADAMTS4 levels. ZBTB20 and KLF3-AS1 were co-expressed in IVDD; ZBTB20 overexpression had similar effects on NP cells, ECM production, and MMP-13 and ADAMTS4 levels as KLF3-AS1 overexpression. miR-10a-3p may target KLF3-AS1 and ZBTB20 and inhibit the expression of ZBTB20. Inhibition of miR-10a-3p enhanced NP cell viability, reduced apoptosis, and enhanced ECM synthesis. KLF3-AS1 overexpression increased ZBTB20 expression, whereas miR-10a-3p overexpression decreased ZBTB20 expression; miR-10a-3p overexpression reduced the effects of KLF3-AS1 on ZBTB20. Overexpression of miR-10a-3p consistently decreased the effects of KLF3-AS1 overexpression on NP cell survival, apoptosis, and ECM synthesis. In conclusion, KLF3-AS1 overexpression may ameliorate degenerative NP cell alterations through the miR-10a-3p/ZBTB20 axis."xsd:string |
| http://purl.uniprot.org/citations/37052702 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00441-023-03751-z"xsd:string |
| http://purl.uniprot.org/citations/37052702 | http://purl.uniprot.org/core/author | "Cao H."xsd:string |
| http://purl.uniprot.org/citations/37052702 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/37052702 | http://purl.uniprot.org/core/author | "Li P."xsd:string |
| http://purl.uniprot.org/citations/37052702 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/37052702 | http://purl.uniprot.org/core/author | "Zheng R."xsd:string |
| http://purl.uniprot.org/citations/37052702 | http://purl.uniprot.org/core/author | "Zeng J."xsd:string |
| http://purl.uniprot.org/citations/37052702 | http://purl.uniprot.org/core/author | "Ding Z."xsd:string |
| http://purl.uniprot.org/citations/37052702 | http://purl.uniprot.org/core/author | "Peng Y."xsd:string |
| http://purl.uniprot.org/citations/37052702 | http://purl.uniprot.org/core/author | "Zhuang Q."xsd:string |
| http://purl.uniprot.org/citations/37052702 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37052702 | http://purl.uniprot.org/core/name | "Cell Tissue Res"xsd:string |
| http://purl.uniprot.org/citations/37052702 | http://purl.uniprot.org/core/pages | "97-109"xsd:string |
| http://purl.uniprot.org/citations/37052702 | http://purl.uniprot.org/core/title | "The long non-coding RNA KLF3-AS1/miR-10a-3p/ZBTB20 axis improves the degenerative changes in human nucleus pulposus cells."xsd:string |
| http://purl.uniprot.org/citations/37052702 | http://purl.uniprot.org/core/volume | "393"xsd:string |
| http://purl.uniprot.org/citations/37052702 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37052702 |
| http://purl.uniprot.org/citations/37052702 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37052702 |
| http://purl.uniprot.org/uniprot/#_A8K251-mappedCitation-37052702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37052702 |
| http://purl.uniprot.org/uniprot/#_B2RCW4-mappedCitation-37052702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37052702 |
| http://purl.uniprot.org/uniprot/#_Q9HC78-mappedCitation-37052702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37052702 |
| http://purl.uniprot.org/uniprot/#_Q8WZ27-mappedCitation-37052702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37052702 |
| http://purl.uniprot.org/uniprot/#_Q9H8V8-mappedCitation-37052702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37052702 |
| http://purl.uniprot.org/uniprot/Q8WZ27 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37052702 |