| http://purl.uniprot.org/citations/37060505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37060505 | http://www.w3.org/2000/01/rdf-schema#comment | "Internal tandem duplication (ITD) is the most common type of FLT3 mutation (FLT3-ITD), accounting for about 25% of AML patients. The expression of DANCR in FLT3-ITD AML had not been paid attention to, and whether its regulatory relationship with IGF2BP2 can affect the progression of FLT3-ITD AML was unclear. Our study sought to verify the biological role of IGF2BP2 as an m6A reading protein in FLT3-ITD AML. To further explore the role and mechanism of DANCR in AML, and provide a basis for the screening of biomarkers and the development of targeted drugs. The results show that IGF2BP2 was upregulated in FLT3-ITD+ AML patients and cells. Si-IGF2BP2 could inhibit the proliferation, glycolytic and promote the apoptosis in MV4-11 cells. IGF2BP2 could promote the DANCR RNA stability. This discovery will provide new horizons for early screening and targeted therapy of FLT3-ITD+ AML."xsd:string |
| http://purl.uniprot.org/citations/37060505 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10495-023-01846-0"xsd:string |
| http://purl.uniprot.org/citations/37060505 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/37060505 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
| http://purl.uniprot.org/citations/37060505 | http://purl.uniprot.org/core/author | "Zhou W."xsd:string |
| http://purl.uniprot.org/citations/37060505 | http://purl.uniprot.org/core/author | "Weng S."xsd:string |
| http://purl.uniprot.org/citations/37060505 | http://purl.uniprot.org/core/author | "Chi C."xsd:string |
| http://purl.uniprot.org/citations/37060505 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37060505 | http://purl.uniprot.org/core/name | "Apoptosis"xsd:string |
| http://purl.uniprot.org/citations/37060505 | http://purl.uniprot.org/core/pages | "1035-1047"xsd:string |
| http://purl.uniprot.org/citations/37060505 | http://purl.uniprot.org/core/title | "IGF2BP2 promotes lncRNA DANCR stability mediated glycolysis and affects the progression of FLT3-ITD + acute myeloid leukemia."xsd:string |
| http://purl.uniprot.org/citations/37060505 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/37060505 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37060505 |
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| http://purl.uniprot.org/uniprot/#_B4DKT5-mappedCitation-37060505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37060505 |
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