| http://purl.uniprot.org/citations/37062520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37062520 | http://www.w3.org/2000/01/rdf-schema#comment | "Thoracic aortic dissection (TAD) is a severe cardiovascular disease attributed to the abnormal phenotypic switch of vascular smooth muscle cells (VSMCs). We found that the RNA-binding protein PUM2 and the fibulin protein EFEMP1 were significantly decreased at the TAD anatomical site. Therefore, we constructed expression and silencing vectors for PUM2 and EFEMP1 to analyze differential expression. Overexpression of PUM2 inhibited VSMC proliferation and migration. Western blot analysis indicated that PUM2 overexpression in VSMCs upregulated α-SMA and SM22α and downregulated OPN and MMP2. Immunofluorescence demonstrated that PUM2 and EFEMP1 were co-expressed in VSMCs. Immunoprecipitation confirmed that PUM2 bound to EFEMP1 mRNA to promote EFEMP1 expression. An Ang-II-induced aortic dissection mouse model showed that PUM2 impedes the development of aortic dissection in vivo. Our study demonstrates that PUM2 inhibits the VSMC phenotypic switch to prevent aortic dissection by targeting EFEMP1 mRNA. These findings could assist the development of targeted therapy for TAD."xsd:string |
| http://purl.uniprot.org/citations/37062520 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2023.113602"xsd:string |
| http://purl.uniprot.org/citations/37062520 | http://purl.uniprot.org/core/author | "Guo H."xsd:string |
| http://purl.uniprot.org/citations/37062520 | http://purl.uniprot.org/core/author | "Qu L."xsd:string |
| http://purl.uniprot.org/citations/37062520 | http://purl.uniprot.org/core/author | "Yin R."xsd:string |
| http://purl.uniprot.org/citations/37062520 | http://purl.uniprot.org/core/author | "Zhi K."xsd:string |
| http://purl.uniprot.org/citations/37062520 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37062520 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/37062520 | http://purl.uniprot.org/core/pages | "113602"xsd:string |
| http://purl.uniprot.org/citations/37062520 | http://purl.uniprot.org/core/title | "PUM2 regulates the formation of thoracic aortic dissection through EFEMP1."xsd:string |
| http://purl.uniprot.org/citations/37062520 | http://purl.uniprot.org/core/volume | "427"xsd:string |
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