| http://purl.uniprot.org/citations/37070943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37070943 | http://www.w3.org/2000/01/rdf-schema#comment | "Fluoride induces endoplasmic reticulum (ER) stress in ameloblasts, which is responsible for enamel mineralization disorder. Fluoride induces autophagy in ameloblasts, but the molecular mechanisms through which ameloblasts respond to fluoride-induced cellular stress and autophagy remain unclear. This study investigated ER stress-induced autophagy and the regulatory role of the ER molecular chaperone GRP78 in fluoride-induced autophagy in ameloblast LS8 cells. To explore the relationship between fluoride-induced ER stress and autophagy, we assessed changes in fluoride-induced autophagy in LS8 cells following overexpression and/or silencing of the ER stress molecular chaperone GRP78. We found that autophagy induced by fluoride was further increased after GRP78 overexpression in LS8 cells. Fluoride-induced autophagy was reduced in GRP78-silenced LS8 cells. Furthermore, we found that ER stress can regulate autophagy in fluoride-treated ameloblasts (LS8 cells) and that the GRP78/IRE1/TRAF2/JNK pathway is involved in the underlying regulation. Our study suggests that ER stress plays a role in fluoride-induced damage by inducing ameloblast autophagy."xsd:string |
| http://purl.uniprot.org/citations/37070943 | http://purl.org/dc/terms/identifier | "doi:10.1002/tox.23805"xsd:string |
| http://purl.uniprot.org/citations/37070943 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/37070943 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/37070943 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/37070943 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/37070943 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/37070943 | http://purl.uniprot.org/core/author | "Zhao L."xsd:string |
| http://purl.uniprot.org/citations/37070943 | http://purl.uniprot.org/core/author | "Ruan J."xsd:string |
| http://purl.uniprot.org/citations/37070943 | http://purl.uniprot.org/core/author | "Xi T."xsd:string |
| http://purl.uniprot.org/citations/37070943 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37070943 | http://purl.uniprot.org/core/name | "Environ Toxicol"xsd:string |
| http://purl.uniprot.org/citations/37070943 | http://purl.uniprot.org/core/pages | "1756-1767"xsd:string |
| http://purl.uniprot.org/citations/37070943 | http://purl.uniprot.org/core/title | "Endoplasmic reticulum chaperone GRP78 participates in fluoride-induced autophagy in LS8 cells by regulating the IRE1-TRAF2-JNK pathway."xsd:string |
| http://purl.uniprot.org/citations/37070943 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/37070943 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37070943 |
| http://purl.uniprot.org/citations/37070943 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37070943 |
| http://purl.uniprot.org/uniprot/#_A3KBF5-mappedCitation-37070943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37070943 |
| http://purl.uniprot.org/uniprot/#_A6P3E4-mappedCitation-37070943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37070943 |
| http://purl.uniprot.org/uniprot/#_P20029-mappedCitation-37070943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37070943 |
| http://purl.uniprot.org/uniprot/#_P39429-mappedCitation-37070943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37070943 |
| http://purl.uniprot.org/uniprot/#_Q32MS5-mappedCitation-37070943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37070943 |
| http://purl.uniprot.org/uniprot/#_G3X8U9-mappedCitation-37070943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37070943 |
| http://purl.uniprot.org/uniprot/#_Q3TI47-mappedCitation-37070943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37070943 |