| http://purl.uniprot.org/citations/37071993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37071993 | http://www.w3.org/2000/01/rdf-schema#comment | "Cortical circuits are composed predominantly of pyramidal-to-pyramidal neuron connections, yet their assembly during embryonic development is not well understood. We show that mouse embryonic Rbp4-Cre cortical neurons, transcriptomically closest to layer 5 pyramidal neurons, display two phases of circuit assembly in vivo. At E14.5, they form a multi-layered circuit motif, composed of only embryonic near-projecting-type neurons. By E17.5, this transitions to a second motif involving all three embryonic types, analogous to the three adult layer 5 types. In vivo patch clamp recordings and two-photon calcium imaging of embryonic Rbp4-Cre neurons reveal active somas and neurites, tetrodotoxin-sensitive voltage-gated conductances, and functional glutamatergic synapses, from E14.5 onwards. Embryonic Rbp4-Cre neurons strongly express autism-associated genes and perturbing these genes interferes with the switch between the two motifs. Hence, pyramidal neurons form active, transient, multi-layered pyramidal-to-pyramidal circuits at the inception of neocortex, and studying these circuits could yield insights into the etiology of autism."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2023.03.025"xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/author | "Munz M."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/author | "Picelli S."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/author | "Krol J."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/author | "Pavlinic D."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/author | "Rodrigues T.M."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/author | "Rozsa B."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/author | "Roska B."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/author | "Bharioke A."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/author | "Moreno-Juan V."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/author | "Graff-Meyer A."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/author | "Brignall A."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/author | "Gross-Scherf B."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/author | "Kosche G."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/author | "Ledergerber N."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/author | "Cowan C.S."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/author | "Haeuselmann S."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/author | "Ulmer T."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/pages | "1930-1949.e31"xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/title | "Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex."xsd:string |
| http://purl.uniprot.org/citations/37071993 | http://purl.uniprot.org/core/volume | "186"xsd:string |