| http://purl.uniprot.org/citations/37076641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37076641 | http://www.w3.org/2000/01/rdf-schema#comment | "Formation and maintenance of skin barrier function require tightly controlled membrane-associated proteolysis, in which the integral membrane Kunitz-type serine protease inhibitor, HAI-1, functions as the primary inhibitor of the membrane-associated serine proteases, matriptase and prostasin. Previously, HAI-1 loss in HaCaT human keratinocytes resulted in an expected increase in prostasin proteolysis but a paradoxical decrease in matriptase proteolysis. The paradoxical decrease in shed active matriptase is further investigated in this study with an unexpected discovery of novel functions of fibroblast growth factor-binding protein 1 (FGFBP1), which acts as an extracellular ligand that can rapidly elicit F-actin rearrangement and subsequently affect the morphology of human keratinocytes. This novel growth factor-like function is in stark contrast to the canonical activity of this protein through interactions with FGFs for its pathophysiological functions. This discovery began with the observation that HAI-1 KO HaCaT cells lose the characteristic cobblestone morphology of the parental cells and exhibit aberrant F-actin formation along with altered subcellular targeting of matriptase and HAI-2. The alterations in cell morphology and F-actin status caused by targeted HAI-1 deletion can be restored by treatment with conditioned medium from parental HaCaT cells, in which FGFBP1 was identified by tandem mass spectrometry. Recombinant FGFBP1 down to 1 ng/ml was able to revert the changes caused by HAI-1 loss. Our study reveals a novel function of FGFBP1 in the maintenance of keratinocyte morphology, which depends on HAI-1."xsd:string |
| http://purl.uniprot.org/citations/37076641 | http://purl.org/dc/terms/identifier | "doi:10.1007/s13577-023-00906-6"xsd:string |
| http://purl.uniprot.org/citations/37076641 | http://purl.uniprot.org/core/author | "Huang N."xsd:string |
| http://purl.uniprot.org/citations/37076641 | http://purl.uniprot.org/core/author | "Lin C.Y."xsd:string |
| http://purl.uniprot.org/citations/37076641 | http://purl.uniprot.org/core/author | "Lai C.H."xsd:string |
| http://purl.uniprot.org/citations/37076641 | http://purl.uniprot.org/core/author | "Johnson M.D."xsd:string |
| http://purl.uniprot.org/citations/37076641 | http://purl.uniprot.org/core/author | "Wang J.K."xsd:string |
| http://purl.uniprot.org/citations/37076641 | http://purl.uniprot.org/core/author | "Li S.A."xsd:string |
| http://purl.uniprot.org/citations/37076641 | http://purl.uniprot.org/core/author | "Lu D.D."xsd:string |
| http://purl.uniprot.org/citations/37076641 | http://purl.uniprot.org/core/author | "Chan K.S."xsd:string |
| http://purl.uniprot.org/citations/37076641 | http://purl.uniprot.org/core/author | "Fang J.R."xsd:string |
| http://purl.uniprot.org/citations/37076641 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37076641 | http://purl.uniprot.org/core/name | "Hum Cell"xsd:string |
| http://purl.uniprot.org/citations/37076641 | http://purl.uniprot.org/core/pages | "1403-1415"xsd:string |
| http://purl.uniprot.org/citations/37076641 | http://purl.uniprot.org/core/title | "HAI-1 is required for the novel role of FGFBP1 in maintenance of cell morphology and F-actin rearrangement in human keratinocytes."xsd:string |
| http://purl.uniprot.org/citations/37076641 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/37076641 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37076641 |
| http://purl.uniprot.org/citations/37076641 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37076641 |
| http://purl.uniprot.org/uniprot/#_B2RBU9-mappedCitation-37076641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37076641 |
| http://purl.uniprot.org/uniprot/#_B4DTF6-mappedCitation-37076641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37076641 |
| http://purl.uniprot.org/uniprot/#_B4E1L9-mappedCitation-37076641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37076641 |
| http://purl.uniprot.org/uniprot/#_O43278-mappedCitation-37076641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37076641 |
| http://purl.uniprot.org/uniprot/#_Q14512-mappedCitation-37076641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37076641 |
| http://purl.uniprot.org/uniprot/B4DTF6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37076641 |