| http://purl.uniprot.org/citations/37080971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37080971 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulin resistance (IR) during obesity is linked to adipose tissue macrophage (ATM)-driven inflammation of adipose tissue. Whether anti-inflammatory glucocorticoids (GCs) at physiological levels modulate IR is unclear. Here, we report that deletion of the GC receptor (GR) in myeloid cells, including macrophages in mice, aggravates obesity-related IR by enhancing adipose tissue inflammation due to decreased anti-inflammatory ATM leading to exaggerated adipose tissue lipolysis and severe hepatic steatosis. In contrast, GR deletion in Kupffer cells alone does not alter IR. Co-culture experiments show that the absence of GR in macrophages directly causes reduced phospho-AKT and glucose uptake in adipocytes, suggesting an important function of GR in ATM. GR-deficient macrophages are refractory to alternative ATM-inducing IL-4 signaling, due to reduced STAT6 chromatin loading and diminished anti-inflammatory enhancer activation. We demonstrate that GR has an important function in macrophages during obesity by limiting adipose tissue inflammation and lipolysis to promote insulin sensitivity."xsd:string |
| http://purl.uniprot.org/citations/37080971 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-37831-z"xsd:string |
| http://purl.uniprot.org/citations/37080971 | http://purl.uniprot.org/core/author | "Rauch A."xsd:string |
| http://purl.uniprot.org/citations/37080971 | http://purl.uniprot.org/core/author | "Kiehntopf M."xsd:string |
| http://purl.uniprot.org/citations/37080971 | http://purl.uniprot.org/core/author | "Tuckermann J.P."xsd:string |
| http://purl.uniprot.org/citations/37080971 | http://purl.uniprot.org/core/author | "Bluher M."xsd:string |
| http://purl.uniprot.org/citations/37080971 | http://purl.uniprot.org/core/author | "Graler M.H."xsd:string |
| http://purl.uniprot.org/citations/37080971 | http://purl.uniprot.org/core/author | "Chung K.J."xsd:string |
| http://purl.uniprot.org/citations/37080971 | http://purl.uniprot.org/core/author | "Caratti G."xsd:string |
| http://purl.uniprot.org/citations/37080971 | http://purl.uniprot.org/core/author | "Stifel U."xsd:string |
| http://purl.uniprot.org/citations/37080971 | http://purl.uniprot.org/core/author | "Caratti B."xsd:string |
| http://purl.uniprot.org/citations/37080971 | http://purl.uniprot.org/core/author | "Jamil A.J.M."xsd:string |
| http://purl.uniprot.org/citations/37080971 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37080971 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/37080971 | http://purl.uniprot.org/core/pages | "2271"xsd:string |
| http://purl.uniprot.org/citations/37080971 | http://purl.uniprot.org/core/title | "Glucocorticoid activation of anti-inflammatory macrophages protects against insulin resistance."xsd:string |
| http://purl.uniprot.org/citations/37080971 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/37080971 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37080971 |
| http://purl.uniprot.org/citations/37080971 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37080971 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-37080971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37080971 |
| http://purl.uniprot.org/uniprot/#_D3Z280-mappedCitation-37080971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37080971 |
| http://purl.uniprot.org/uniprot/#_A0A0R4IZZ5-mappedCitation-37080971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37080971 |
| http://purl.uniprot.org/uniprot/#_A0A385HBV1-mappedCitation-37080971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37080971 |
| http://purl.uniprot.org/uniprot/#_A0A494B9W1-mappedCitation-37080971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37080971 |