| http://purl.uniprot.org/citations/37081375 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37081375 | http://www.w3.org/2000/01/rdf-schema#comment | "Increasing evidence suggests that PCSK9 inhibition protects cardiomyocytes against ischemia-reperfusion injury after myocardial infarction. However, it is not clear whether PCSK9 inhibitor (PCSK9i) affects cardiac fibroblasts (CFs) activation after MI. In this study we used SBC-115076, an antagonist of PCSK9, to investigate the role of PCSK9i in the conversion of CFs to cardiac myofibroblasts (CMFs) after MI and provided a basic for its clinical application in cardiac fibrosis after MI. In vivo study, PCSK9i was injected into mice 4 days after MI. Cardiac function and degree of fibrosis were evaluated by echocardiographic and tissue staining after treatment. Western blot showed that PCSK9i treatment decreases expression of α-SMA, collagen and increases expression of Notch1 in border infarct area. Vitro studies showed that PCSK9i decreased the degree of fibrosis, migration, and collagen fiber deposition in CFs. Confocal microscopy imaging also showed that hypoxia contributes to the formation of α-SMA stress filaments, and PCSK9i alleviated this state. Moreover, overexpression of Notch1 further suppress the activation of CFs under hypoxia. These results revealed that SBC-115076 ameliorates cardiac fibrosis and ventricular dysfunction post-myocardial infarction through inhibition of the differentiation of cardiac fibroblasts to myofibroblasts via Notch1/Hes1 signaling."xsd:string |
| http://purl.uniprot.org/citations/37081375 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12013-023-01136-1"xsd:string |
| http://purl.uniprot.org/citations/37081375 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/37081375 | http://purl.uniprot.org/core/author | "Ji J."xsd:string |
| http://purl.uniprot.org/citations/37081375 | http://purl.uniprot.org/core/author | "Lin D."xsd:string |
| http://purl.uniprot.org/citations/37081375 | http://purl.uniprot.org/core/author | "Jiang F."xsd:string |
| http://purl.uniprot.org/citations/37081375 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/37081375 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/37081375 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37081375 | http://purl.uniprot.org/core/name | "Cell Biochem Biophys"xsd:string |
| http://purl.uniprot.org/citations/37081375 | http://purl.uniprot.org/core/pages | "359-369"xsd:string |
| http://purl.uniprot.org/citations/37081375 | http://purl.uniprot.org/core/title | "PCSK9 Inhibition Regulates Infarction-Induced Cardiac Myofibroblast Transdifferentiation via Notch1 Signaling."xsd:string |
| http://purl.uniprot.org/citations/37081375 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/37081375 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37081375 |
| http://purl.uniprot.org/citations/37081375 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37081375 |
| http://purl.uniprot.org/uniprot/#_Q5PYH4-mappedCitation-37081375 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37081375 |
| http://purl.uniprot.org/uniprot/#_Q80W65-mappedCitation-37081375 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37081375 |
| http://purl.uniprot.org/uniprot/Q80W65 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37081375 |
| http://purl.uniprot.org/uniprot/Q5PYH4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37081375 |