| http://purl.uniprot.org/citations/37105172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37105172 | http://www.w3.org/2000/01/rdf-schema#comment | "In neurodegenerative diseases, microglia switch to an activated state, which results in excessive secretion of pro-inflammatory factors. Our work aims to investigate how this paracrine signaling affects neuronal function. Here, we show that activated microglia mediate non-cell-autonomous inhibition of neuronal autophagy, a degradative pathway critical for the removal of toxic, aggregate-prone proteins accumulating in neurodegenerative diseases. We found that the microglial-derived CCL-3/-4/-5 bind and activate neuronal CCR5, which in turn promotes mTORC1 activation and disrupts autophagy and aggregate-prone protein clearance. CCR5 and its cognate chemokines are upregulated in the brains of pre-manifesting mouse models for Huntington's disease (HD) and tauopathy, suggesting a pathological role of this microglia-neuronal axis in the early phases of these diseases. CCR5 upregulation is self-sustaining, as CCL5-CCR5 autophagy inhibition impairs CCR5 degradation itself. Finally, pharmacological or genetic inhibition of CCR5 rescues mTORC1 hyperactivation and autophagy dysfunction, which ameliorates HD and tau pathologies in mouse models."xsd:string |
| http://purl.uniprot.org/citations/37105172 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2023.04.006"xsd:string |
| http://purl.uniprot.org/citations/37105172 | http://purl.uniprot.org/core/author | "Rubinsztein D.C."xsd:string |
| http://purl.uniprot.org/citations/37105172 | http://purl.uniprot.org/core/author | "Won H."xsd:string |
| http://purl.uniprot.org/citations/37105172 | http://purl.uniprot.org/core/author | "Jimenez-Sanchez M."xsd:string |
| http://purl.uniprot.org/citations/37105172 | http://purl.uniprot.org/core/author | "Stamatakou E."xsd:string |
| http://purl.uniprot.org/citations/37105172 | http://purl.uniprot.org/core/author | "Siddiqi F.H."xsd:string |
| http://purl.uniprot.org/citations/37105172 | http://purl.uniprot.org/core/author | "Festa B.P."xsd:string |
| http://purl.uniprot.org/citations/37105172 | http://purl.uniprot.org/core/author | "Djajadikerta A."xsd:string |
| http://purl.uniprot.org/citations/37105172 | http://purl.uniprot.org/core/author | "Rob M."xsd:string |
| http://purl.uniprot.org/citations/37105172 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37105172 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/37105172 | http://purl.uniprot.org/core/pages | "2021-2037.e12"xsd:string |
| http://purl.uniprot.org/citations/37105172 | http://purl.uniprot.org/core/title | "Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration."xsd:string |
| http://purl.uniprot.org/citations/37105172 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/37105172 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37105172 |
| http://purl.uniprot.org/citations/37105172 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37105172 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SS26-mappedCitation-37105172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37105172 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J063-mappedCitation-37105172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37105172 |
| http://purl.uniprot.org/uniprot/#_P70379-mappedCitation-37105172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37105172 |
| http://purl.uniprot.org/uniprot/#_E9Q351-mappedCitation-37105172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37105172 |
| http://purl.uniprot.org/uniprot/#_E9Q3E5-mappedCitation-37105172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37105172 |
| http://purl.uniprot.org/uniprot/#_P51682-mappedCitation-37105172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37105172 |
| http://purl.uniprot.org/uniprot/#_O89096-mappedCitation-37105172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37105172 |