| http://purl.uniprot.org/citations/37115584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37115584 | http://www.w3.org/2000/01/rdf-schema#comment | "Hematopoietic stem cells (HSC) and downstream lineage-biased multipotent progenitors (MPP) tailor blood production and control myelopoiesis on demand. Recent lineage tracing analyses revealed MPPs to be major functional contributors to steady-state hematopoiesis. However, we still lack a precise resolution of myeloid differentiation trajectories and cellular heterogeneity in the MPP compartment. Here, we found that myeloid-biased MPP3 are functionally and molecularly heterogeneous, with a distinct subset of myeloid-primed secretory cells with high endoplasmic reticulum (ER) volume and FcγR expression. We show that FcγR+/ERhigh MPP3 are a transitional population serving as a reservoir for rapid production of granulocyte/macrophage progenitors (GMP), which directly amplify myelopoiesis through inflammation-triggered secretion of cytokines in the local bone marrow (BM) microenvironment. Our results identify a novel regulatory function for a secretory MPP3 subset that controls myeloid differentiation through lineage-priming and cytokine production and acts as a self-reinforcing amplification compartment in inflammatory stress and disease conditions."xsd:string |
| http://purl.uniprot.org/citations/37115584 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20230088"xsd:string |
| http://purl.uniprot.org/citations/37115584 | http://purl.uniprot.org/core/author | "Fan R."xsd:string |
| http://purl.uniprot.org/citations/37115584 | http://purl.uniprot.org/core/author | "Zhang S.Y."xsd:string |
| http://purl.uniprot.org/citations/37115584 | http://purl.uniprot.org/core/author | "Chen J.J."xsd:string |
| http://purl.uniprot.org/citations/37115584 | http://purl.uniprot.org/core/author | "Mitchell C.A."xsd:string |
| http://purl.uniprot.org/citations/37115584 | http://purl.uniprot.org/core/author | "Collins A."xsd:string |
| http://purl.uniprot.org/citations/37115584 | http://purl.uniprot.org/core/author | "Kang Y.A."xsd:string |
| http://purl.uniprot.org/citations/37115584 | http://purl.uniprot.org/core/author | "Passegue E."xsd:string |
| http://purl.uniprot.org/citations/37115584 | http://purl.uniprot.org/core/author | "Warr M.R."xsd:string |
| http://purl.uniprot.org/citations/37115584 | http://purl.uniprot.org/core/author | "Swann J.W."xsd:string |
| http://purl.uniprot.org/citations/37115584 | http://purl.uniprot.org/core/author | "Olson O.C."xsd:string |
| http://purl.uniprot.org/citations/37115584 | http://purl.uniprot.org/core/author | "Paik H."xsd:string |
| http://purl.uniprot.org/citations/37115584 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37115584 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/37115584 | http://purl.uniprot.org/core/pages | "e20230088"xsd:string |
| http://purl.uniprot.org/citations/37115584 | http://purl.uniprot.org/core/title | "Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production."xsd:string |
| http://purl.uniprot.org/citations/37115584 | http://purl.uniprot.org/core/volume | "220"xsd:string |
| http://purl.uniprot.org/citations/37115584 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37115584 |
| http://purl.uniprot.org/citations/37115584 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37115584 |
| http://purl.uniprot.org/uniprot/#_D3YVT4-mappedCitation-37115584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37115584 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-37115584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37115584 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-37115584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37115584 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRE5-mappedCitation-37115584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37115584 |