| http://purl.uniprot.org/citations/37116235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37116235 | http://www.w3.org/2000/01/rdf-schema#comment | "CD11b+Gr-1low cells that are increased in the lungs of a Mycobacterium (M) tuberculosis-infection mouse model have the characteristics of monocytic (M)-myeloid-derived suppressor cells (MDSCs) and harbor M.tuberculosis. Interestingly, a high number of M-MDSCs have also been observed in skin lesions of patients with lepromatous leprosy. We hypothesized that CD11b+Gr-1low cells might be involved in the pathogenesis of leprosy, as they are in tuberculosis. In the current study, we investigated the issue of whether CD11b+Gr-1low cells accumulate in Mycobacterium (M) leprae-induced granulomas of the footpad skin of nude mice. Our results show that CD11b+Gr-1low cells began to accumulate in the 7-month-old M.leprae-induced granulomas and were replaced by other leukocytes, including CD11b+Gr-1high over time during M.leprae infections. CD11b + Gr-1low cells expressed the surface markers of M-MDSC, Ly6Chigh and Ly6Glow. In addition, CD11b+Gr-1low cells have the nuclei of a mononuclear cell type and expressed higher levels of arginase 1 (Arg1) and inducible NO synthetase (iNOS). Furthermore, they showed a higher infection rate by M.leprae. Taken together, our results indicate that the inoculation with M.leprae induced an accumulation of CD11b + Gr-1low at a relatively early stage, 7-month-old M.leprae-induced granulomas, and that CD11b+Gr-1low have the characteristics of M-MDSC and may act as a reservoir for M.leprae."xsd:string |
| http://purl.uniprot.org/citations/37116235 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.tube.2023.102345"xsd:string |
| http://purl.uniprot.org/citations/37116235 | http://purl.uniprot.org/core/author | "Lee S.B."xsd:string |
| http://purl.uniprot.org/citations/37116235 | http://purl.uniprot.org/core/author | "Jin S.H."xsd:string |
| http://purl.uniprot.org/citations/37116235 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37116235 | http://purl.uniprot.org/core/name | "Tuberculosis (Edinb)"xsd:string |
| http://purl.uniprot.org/citations/37116235 | http://purl.uniprot.org/core/pages | "102345"xsd:string |
| http://purl.uniprot.org/citations/37116235 | http://purl.uniprot.org/core/title | "CD11b+Gr-1low cells that accumulate in M.leprae-induced granulomas of the footpad skin of nude mice have the characteristics of monocytic-myeloid-derived suppressor cells."xsd:string |
| http://purl.uniprot.org/citations/37116235 | http://purl.uniprot.org/core/volume | "140"xsd:string |
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