| http://purl.uniprot.org/citations/37117185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37117185 | http://www.w3.org/2000/01/rdf-schema#comment | "Understanding the factors and mechanisms involved in beta-cell development will guide therapeutic efforts to generate fully functional beta cells for diabetes. Neurogenin 3 (NGN3) is the key transcription factor that marks endocrine progenitors and drives beta-cell differentiation. Here we screen for binding partners of NGN3 and identify the deubiquitylating enzyme USP7 as a key regulator of NGN3 stability. Mechanistically, USP7 interacts with, deubiquitinates and stabilizes NGN3. In vivo, conditional knockout of Usp7 in the mouse embryonic pancreas causes a dramatic reduction in islet formation and hyperglycemia in adult mice, due to impaired NGN3-mediated endocrine specification during pancreatic development. Furthermore, pharmacological inhibition of USP7 during endocrine specification in human iPSC models of beta-cell differentiation decreases NGN3 expressing progenitor cell numbers and impairs beta cell differentiation. Thus, the USP7-NGN3 axis is an essential mechanism for driving endocrine development and beta-cell differentiation, which can be therapeutically exploited."xsd:string |
| http://purl.uniprot.org/citations/37117185 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-38146-9"xsd:string |
| http://purl.uniprot.org/citations/37117185 | http://purl.uniprot.org/core/author | "Behrens A."xsd:string |
| http://purl.uniprot.org/citations/37117185 | http://purl.uniprot.org/core/author | "Hansson K."xsd:string |
| http://purl.uniprot.org/citations/37117185 | http://purl.uniprot.org/core/author | "Evans I."xsd:string |
| http://purl.uniprot.org/citations/37117185 | http://purl.uniprot.org/core/author | "Sancho R."xsd:string |
| http://purl.uniprot.org/citations/37117185 | http://purl.uniprot.org/core/author | "Nelson J.K."xsd:string |
| http://purl.uniprot.org/citations/37117185 | http://purl.uniprot.org/core/author | "Garrone C.M."xsd:string |
| http://purl.uniprot.org/citations/37117185 | http://purl.uniprot.org/core/author | "Manea T."xsd:string |
| http://purl.uniprot.org/citations/37117185 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37117185 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/37117185 | http://purl.uniprot.org/core/pages | "2457"xsd:string |
| http://purl.uniprot.org/citations/37117185 | http://purl.uniprot.org/core/title | "USP7 controls NGN3 stability and pancreatic endocrine lineage development."xsd:string |
| http://purl.uniprot.org/citations/37117185 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/37117185 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37117185 |
| http://purl.uniprot.org/citations/37117185 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37117185 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQV9-mappedCitation-37117185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37117185 |
| http://purl.uniprot.org/uniprot/#_D3Z116-mappedCitation-37117185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37117185 |
| http://purl.uniprot.org/uniprot/#_D3Z595-mappedCitation-37117185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37117185 |
| http://purl.uniprot.org/uniprot/#_D3Z596-mappedCitation-37117185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37117185 |
| http://purl.uniprot.org/uniprot/#_E0CXX7-mappedCitation-37117185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37117185 |
| http://purl.uniprot.org/uniprot/#_E0CY04-mappedCitation-37117185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37117185 |
| http://purl.uniprot.org/uniprot/#_D3YWU5-mappedCitation-37117185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37117185 |
| http://purl.uniprot.org/uniprot/#_P52946-mappedCitation-37117185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37117185 |